PRDM4 - PR/SET domain 4 Gene

Homo sapiens

Also known as PFM1

Gene ID: 11108 | Gene type: protein coding

About PRDM4

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:107,732,871-107,761,137 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 51 paralogues. Ubiquitous expression in kidney (RPKM 10.4), esophagus (RPKM 8.7) and 25 other tissues.

Summary

The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]

PRDM4 Products(1)

mRNA	Protein	Name
NM_012406.4	NP_036538.3	PR domain zinc finger protein 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDM4 Protein Structure

zf-H2C2_2

zf-C2H2

0
200
400
600
801 a.a.

Protein Preferred Names

Protein Names

PR domain zinc finger protein 4

PR domain 4

PRDM4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRDM4	Q9UKN5	CTNNBL1	Homo sapiens	Q8WYA6	Y2H Prey Pooling	25416956
Intra	PRDM4	Q9UKN5	MSRB3	Homo sapiens	Q8IXL7	Validated Y2H	25416956
Intra	PRDM4	Q9UKN5	MSRB3	Homo sapiens	Q8IXL7	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11068	PRDM4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRDM4	MGD	MGI:1920093
Canis familiaris	PRDM4	VGNC	VGNC:44949
Bos taurus	PRDM4	VGNC	VGNC:33296
Felis catus	PRDM4	VGNC	VGNC:69034
Macaca mulatta	PRDM4	VGNC	VGNC:76393
Rattus norvegicus	PRDM4	RGD	RGD:619929

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