2. Gene
  3. CAPN11 - calpain 11 Gene

CAPN11 - calpain 11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as calpain11

Gene ID: 11131 | Gene type: protein coding

About CAPN11

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,158,820-44,184,401 (from NCBI)

This gene has 5 transcripts (splice variants), 271 orthologues and 20 paralogues. Restricted expression toward testis (RPKM 18.7).

Summary

Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]

CAPN11 Products(1)

mRNA Protein Name
NM_007058.4 NP_008989.2 calpain-11

CAPN11 Protein Structure

Peptidase_C2

Peptidase_C2: Calpain family cysteine protease (79 - 378)

Calpain_III

Calpain_III: Calpain large subunit, domain III (390 - 546)

EF-hand_8

EF-hand_8: EF-hand domain pair (600 - 641)

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  • 739 a.a.
Protein Preferred Names Protein Names

calpain-11

CANP 11

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01885 CAPN11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CAPN11 VGNC VGNC:70531
Mus musculus CAPN11 MGD MGI:1352490
Felis catus CAPN11 VGNC VGNC:60350
Rattus norvegicus CAPN11 RGD RGD:1302946
Canis familiaris CAPN11 VGNC VGNC:38700
Bos taurus CAPN11 VGNC VGNC:26742