PWP1 - PWP1 homolog, endonuclein Gene

Homo sapiens

Also known as NCLB; IEF-SSP-9502

Gene ID: 11137 | Gene type: protein coding

About PWP1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:107,685,799-107,713,162 (from NCBI)

This gene has 5 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in testis (RPKM 14.1), brain (RPKM 13.4) and 25 other tissues.

Summary

The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

PWP1 Products(3)

mRNA	Protein	Name
NM_001317962.2	NP_001304891.1	periodic tryptophan protein 1 homolog isoform 2
NM_001317963.2	NP_001304892.1	periodic tryptophan protein 1 homolog isoform 3
NM_007062.3	NP_008993.1	periodic tryptophan protein 1 homolog isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	IDA IDA: Inferred from direct assay	29065309	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	29065309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PWP1 Protein Structure

WD40

0
100
200
300
400
501 a.a.

Protein Preferred Names

Protein Names

periodic tryptophan protein 1 homolog

endonuclein

PWP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82039	PWP1 Antibody (YA1784)	WB	Human

Related Diseases

Diseases

Alias

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11475	PWP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PWP1	VGNC	VGNC:45215
Bos taurus	PWP1	VGNC	VGNC:33580
Felis catus	PWP1	VGNC	VGNC:64442
Mus musculus	PWP1	MGD	MGI:1914735
Rattus norvegicus	PWP1	RGD	RGD:1310705

Name
Email *

	Sorry, but the email address you supplied was invalid.