NUDT6 - nudix hydrolase 6 Gene

Homo sapiens

Also known as GFG1; GFG-1; ASFGF2; FGF-AS; FGF2AS

Gene ID: 11162 | Gene type: protein coding

About NUDT6

Cytogenetic location: 4q28.1 Genomic coordinates (GRCh38): 4:122,892,577-122,922,968 (from NCBI)

This gene has 8 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in fat (RPKM 12.5), kidney (RPKM 8.8) and 23 other tissues.

Summary

This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

NUDT6 Products(2)

mRNA	Protein	Name
NM_007083.5	NP_009014.2	nucleoside diphosphate-linked moiety X motif 6 isoform a
NM_198041.3	NP_932158.1	nucleoside diphosphate-linked moiety X motif 6 isoform b

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell cycle	IDA IDA: Inferred from direct assay	11266510	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11266510	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11266510	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT6 Protein Structure

NUDIX

0
100
200
316 a.a.

Protein Preferred Names

Protein Names

nucleoside diphosphate-linked moiety X motif 6

antisense basic fibroblast growth factor

Related Diseases

Diseases

Alias

Desmoid Disease, Hereditary

Fif	DESMD
Hereditary Desmoid Disease	Familial Infiltrative Fibromatosis
Fibromatosis, Familial Infiltrative	Fibromatosis, Aggressive

Gingival Overgrowth

Gingival Enlargement	Gingival Hyperplasia
Gingival Bulge	Gingival Enlargement Nos
Gingival Hypertrophy	Gum Hypertrophy
Hyperplasia Gum	Gingival Thickening
Hyperplasia Of Gingiva	Hypertrophy Of Gingiva
Hypertrophy Of Mucous Membrane Of Gums

Central Neurocytoma

Neurocytoma	Neurolipocytoma
Neurocytoma Central

Gastric Ulcer

Stomach Ulcer	Acute Gastric Ulcer With Haemorrhage And Perforation
Acute Gastric Ulcer With Hemorrhage And Obstruction	Acute Gastric Ulcer With Hemorrhage And Perforation
Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction	Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction
Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction	Acute Gastric Ulcer With Hemorrhage, With Obstruction
Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction	Acute Gastric Ulcer With Perforation
Acute Gastric Ulcer With Perforation And Obstruction	Acute Gastric Ulcer With Perforation, With Obstruction
Acute Gastric Ulcer Without Hemorrhage And Without Perforation	Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction
Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction	Bleeding Acute Gastric Ulcer
Chronic Gastric Ulcer Without Hemorrhage And Without Perforation	Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction
Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction	Gastric Ulcers
Cushings Ulcer	Cushing'S Ulcer Of Stomach
Peptic Ulcer Of Stomach	Mucosal Defect Of The Stomach

Glioma

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1	MEN1
Wermer Syndrome	Multiple Endocrine Neoplasia 1
Multiple Endocrine Neoplasia, Type 1	Men I
Endocrine Adenomatosis, Multiple	Mea I
Men Type I	Wermer'S Syndrome
Men1 Syndrome	Multiple Endocrine Adenomatosis
Endocrine Adenomatosis Multiple	Men 1
Familial Multiple Endocrine Neoplasia Type I	Neoplasia, Endocrine, Multiple, Type 1
Multiple Endocrine Neoplasia

Cartilage Cancer

Chondrogenic Neoplasm

Retinal Degeneration

Degeneration Of Retina

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09674	NUDT6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NUDT6	RGD	RGD:621356
Bos taurus	NUDT6	VGNC	VGNC:32340
Felis catus	NUDT6	VGNC	VGNC:78540
Macaca mulatta	NUDT6	VGNC	VGNC:75553
Mus musculus	NUDT6	MGD	MGI:2387618
Canis familiaris	NUDT6	VGNC	VGNC:54811

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