SOX21 - SRY-box transcription factor 21 Gene

Homo sapiens

Also known as SOX25

Gene ID: 11166 | Gene type: protein coding

About SOX21

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:94,709,622-94,712,545 (from NCBI)

This gene has 1 transcript (splice variant), 164 orthologues, 20 paralogues and is associated with 37 phenotypes.

Summary

SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]

SOX21 Products(1)

mRNA	Protein	Name
NM_007084.4	NP_009015.1	transcription factor SOX-21

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in stem cell differentiation	IDA IDA: Inferred from direct assay	20876214	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOX21 Protein Structure

HMG_box

SOXp

0
100
200
276 a.a.

Protein Preferred Names

Protein Names

transcription factor SOX-21

SOX-A

Related Diseases

Diseases

Alias

Lambert-Eaton Myasthenic Syndrome

Lambert-Eaton Syndrome	Eaton-Lambert Syndrome
Lems	Lambert Eaton Myasthenic Syndrome
Eaton Lambert Syndrome	Lambert Eaton Syndrome
Myasthenic Syndrome Of Lambert-Eaton	Myasthenic-Myopathic Syndrome Of Lambert-Eaton
Lems - [Lambert-Eaton Myasthenic Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13592	SOX21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SOX21	VGNC	VGNC:102327
Mus musculus	SOX21	MGD	MGI:2654070
Bos taurus	SOX21	VGNC	VGNC:35147
Macaca mulatta	SOX21	VGNC	VGNC:106298
Rattus norvegicus	SOX21	RGD	RGD:1304724

Name
Email *

	Sorry, but the email address you supplied was invalid.