ADAMTS7 - ADAM metallopeptidase with thrombospondin type 1 motif 7 Gene

Homo sapiens

Also known as ADAM-TS7; ADAMTS-7; ADAM-TS 7

Gene ID: 11173 | Gene type: protein coding

About ADAMTS7

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,759,206-78,811,464 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 25 paralogues. Broad expression in endometrium (RPKM 4.6), heart (RPKM 3.1) and 20 other tissues.

Summary

The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature Enzyme. This Enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]

ADAMTS7 Products(1)

mRNA	Protein	Name
NM_014272.5	NP_055087.2	A disintegrin and metalloproteinase with thrombospondin motifs 7 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	18485748	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18485748	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to BMP stimulus	IDA IDA: Inferred from direct assay	22247065	GOA
involved in cellular response to interleukin-1	IMP IMP: Inferred from mutant phenotype	18485748	GOA
involved in cellular response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	18485748	GOA
involved in negative regulation of chondrocyte differentiation	IDA IDA: Inferred from direct assay	22247065	GOA
involved in proteolysis involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	18485748	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAMTS7 Protein Structure

Pep_M12B_propep

Reprolysin

TSP_1

ADAM_spacer1

TSP_1

0
300
600
900
1200
1500
1686 a.a.

Protein Preferred Names

Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 7

COMPase

Related Diseases

Diseases

Alias

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Weill-Marchesani Syndrome

Gemss Syndrome	Spherophakia-Brachymorphia Syndrome
Marchesani-Weill Syndrome	Wms
Congenital Mesodermal Dystrophy	Mesodermal Dysmorphodystrophy, Congenital
Spherophakia Brachymorphia Syndrome	Mesodermal Dysmorphodystrophy Congenital
Wm Syndrome	Brachydactyly-Spherophakia Syndrome
Brachymorphy With Spherophakia Syndrome	Congenital Mesodermal Dysmorphodystrophy
Marchesani Syndrome	Weill-Marchesani Syndrome, Autosomal Recessive
Weill-Marchesani Syndrome, Autosomal Dominant

Multiple Epiphyseal Dysplasia

Med	Polyepiphyseal Dysplasia
Edm	Epiphyseal Dysplasia, Multiple, 1
Epiphyseal Dysplasia, Multiple, 2	Epiphyseal Dysplasia, Multiple, 3
Epiphyseal Dysplasia, Multiple, 4	Epiphyseal Dysplasia, Multiple, 5
Epiphyseal Dysplasia, Multiple	Edm1
Edm2	Edm3
Edm4	Edm5
Epiphyseal Dysplasia, Fairbank Type	Epiphyseal Dysplasia, Ribbing Type
Multiple Epiphyseal Dysplasia, Autosomal Dominant	Multiple Epiphyseal Dysplasia, Autosomal Recessive
Rmed	Dysplasia, Epiphyseal, Multiple
Osteochondrodysplasias

Geleophysic Dysplasia

Geleophysic Dwarfism

Gphysd

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162284	BAY-9835	Antagonist	99.46%	Unkown
HY-168003	ADAMTS7-IN-1	Inhibitor	/	Unkown
HY-RS00307	ADAMTS7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADAMTS7	MGD	MGI:1347346
Macaca mulatta	ADAMTS7	VGNC	VGNC:82098
Canis familiaris	ADAMTS7	VGNC	VGNC:37603
Rattus norvegicus	ADAMTS7	RGD	RGD:1306713
Bos taurus	ADAMTS7	VGNC	VGNC:57155
Felis catus	ADAMTS7	VGNC	VGNC:82366
Others	ADAMTS7	NCBI

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