2. Gene
  3. WDR6 - WD repeat domain 6 Gene

WDR6 - WD repeat domain 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Trm734

Gene ID: 11180 | Gene type: protein coding

About WDR6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,007,391-49,015,951 (from NCBI)

This gene has 22 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in ovary (RPKM 54.4), endometrium (RPKM 45.4) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

WDR6 Products(3)

mRNA Protein Name
NM_001320546.3 NP_001307475.1 WD repeat-containing protein 6 isoform 2
NM_001320547.2 NP_001307476.1 WD repeat-containing protein 6 isoform 3
NM_018031.6 NP_060501.4 WD repeat-containing protein 6 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme regulator activity IDA
IDA: Inferred from direct assay
32558197 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17216128 GOA
enables tRNA binding IDA
IDA: Inferred from direct assay
32558197 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of negative effect G1 to G0 transition IPI
IPI: Inferred from physical interaction
17216128 GOA
involved in negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
22354037 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
17216128 GOA
involved in wobble position ribose methylation IDA
IDA: Inferred from direct assay
32558197 GOA
Cellular Component GO Annotation Evidence Reference Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
18850735 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17216128 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR6 Protein Structure

WD40

WD40: WD domain, G-beta repeat (204 - 237)

WD40

WD40: WD domain, G-beta repeat (255 - 284)

WD40

WD40: WD domain, G-beta repeat (300 - 326)

WD40

WD40: WD domain, G-beta repeat (971 - 1010)

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  • 1000
  • 1121 a.a.
Protein Preferred Names Protein Names

WD repeat-containing protein 6

Trm734 homolog

WDR6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
WDR6 Q9NNW5 PTPN3 Homo sapiens P26045
Y2H Prey Pooling
32296183
Intra
WDR6 Q9NNW5 PTPN3 Homo sapiens P26045
Y2H Array
25416956
Intra
WDR6 Q9NNW5 PTPN3 Homo sapiens P26045
Y2H Array
32296183
Intra
WDR6 Q9NNW5 PTPN3 Homo sapiens P26045
Validated Y2H
25416956
Intra
WDR6 Q9NNW5 PTPN3 Homo sapiens P26045
Y2H Prey Pooling
25416956
Intra
WDR6 Q9NNW5 GRIP1 Homo sapiens Q9Y3R0-3
Y2H Prey Pooling
32296183
Intra
WDR6 Q9NNW5 GRIP1 Homo sapiens Q9Y3R0-3
Validated Y2H
32296183
Intra
WDR6 Q9NNW5 GRIP1 Homo sapiens Q9Y3R0-3
Y2H Array
32296183
Intra
WDR6 Q9NNW5 STK11 Homo sapiens Q15831
Y2H
17216128
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tumoral Calcinosis, Normophosphatemic, Familial

Normophosphatemic Familial Tumoral Calcinosis

NFTC

Tumoral Calcinosis, Familial, Normophosphatemic

Calcinosis, Tumoral, With Normophosphatemia

Familial Normophosphatemic Tumoral Calcinosis

Tumoral Calcinosis With Normophosphatemia
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency

Nadh:Q(1) Oxidoreductase Deficiency

MC1DN1

Nadh-Coenzyme Q Reductase Deficiency

Isolated Mitochondrial Respiratory Chain Complex I Deficiency

Isolated Nadh-Coenzyme Q Reductase Deficiency

Isolated Nadh-Coq Reductase Deficiency

Isolated Nadh-Ubiquinone Reductase Deficiency

Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

Nuclear Type Mitochondrial Complex I Deficiency 1

Isolated Complex I Deficiency

Complex 1 Mitochondrial Respiratory Chain Deficiency

Nadh Coenzyme Q Reductase Deficiency

Complex I Mitochondrial Respiratory Chain Deficiency

Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

Nadh:Ubiquinone Oxidoreductase Deficiency

Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15790 WDR6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus WDR6 VGNC VGNC:36908
Macaca mulatta WDR6 VGNC VGNC:78790
Rattus norvegicus WDR6 RGD RGD:1307649
Mus musculus WDR6 MGD MGI:1930140
Canis familiaris WDR6 VGNC VGNC:48378
Felis catus WDR6 VGNC VGNC:67043