SLC2A6 - solute carrier family 2 member 6 Gene

Homo sapiens

Also known as GLUT6; GLUT9; HSA011372

Gene ID: 11182 | Gene type: protein coding

About SLC2A6

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:133,471,094-133,479,099 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 295 orthologues and 13 paralogues. Broad expression in spleen (RPKM 3.2), appendix (RPKM 3.1) and 22 other tissues.

Summary

Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM, Jul 2002]

SLC2A6 Products(2)

mRNA	Protein	Name
NM_001145099.2	NP_001138571.1	solute carrier family 2, facilitated glucose transporter member 6 isoform 2
NM_017585.4	NP_060055.2	solute carrier family 2, facilitated glucose transporter member 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	30431159	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	30431159	GOA
involved in regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	30431159	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in lysosomal membrane	IDA IDA: Inferred from direct assay	30431159	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC2A6 Protein Structure

Sugar_tr

0
100
200
300
400
507 a.a.

Protein Preferred Names

Protein Names

solute carrier family 2, facilitated glucose transporter member 6

GLUT-6

Related Diseases

Diseases

Alias

Endometrial Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of Endometrium

Testis Seminoma

Seminoma Of Testis	Seminoma Testis
Testicular Seminoma Pure	Seminoma

Arterial Tortuosity Syndrome

Arterial Tortuosity	Ats
ATORS	Tortuosity, Arterial, Syndrome

Fanconi Syndrome

Infantile Nephropathic Cystinosis	Adult Fanconi Syndrome
Congenital Fanconi Syndrome	De Toni-Fanconi Syndrome
Fanconi-De Toni Syndrome	Lignac-Fanconi Syndrome
Fanconi Renotubular Syndrome	Primary Fanconi Renotubular Syndrome
De Toni-Debre-Fanconi Syndrome	Adult Fanconi Anemia
Detoni Fanconi Syndrome	Fanconi-De-Toni Syndrome
Primary Fanconi Syndrome	Detoni-Debre-Fanconi Syndrome
Primary Fanconi Renal Syndrome	Fanconi Anemia
Cystinosis, Infantile Nephropathic	Fanconi-Bickel Syndrome
Renal Fanconi Syndrome	Lowe-Bickel Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13175	SLC2A6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC2A6	VGNC	VGNC:82238
Rattus norvegicus	SLC2A6	RGD	RGD:1309317
Mus musculus	SLC2A6	MGD	MGI:2443286
Felis catus	SLC2A6	VGNC	VGNC:65305
Canis familiaris	SLC2A6	VGNC	VGNC:46343
Bos taurus	SLC2A6	VGNC	VGNC:34802

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