TREX2 - three prime repair exonuclease 2 Gene

Homo sapiens

Gene ID: 11219 | Gene type: protein coding

About TREX2

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,444,473-153,446,056 (from NCBI)

This gene has 7 transcripts (splice variants), 176 orthologues and 1 paralogue. Biased expression in skin (RPKM 5.9), spleen (RPKM 0.7) and 5 other tissues.

Summary

This gene encodes a nuclear protein with 3' to 5' exonuclease activity. The encoded protein participates in double-stranded DNA break repair, and may interact with DNA Polymerase delta. [provided by RefSeq, Nov 2012]

TREX2 Products(1)

mRNA	Protein	Name
NM_080701.4	NP_542432.2	three prime repair exonuclease 2

TREX2 Protein Structure

RNase_T

0
100
200
279 a.a.

Protein Preferred Names

Protein Names

three prime repair exonuclease 2

3'-5' exonuclease TREX2 long form

TREX2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TREX2	Q9BQ50	MESD	Homo sapiens	Q14696	Y2H Array	32296183
Intra	TREX2	Q9BQ50	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Laryngeal Benign Neoplasm

Laryngeal Tumor	Larynx Neoplasm
Neoplasm Of Larynx	Laryngeal Cancer
Laryngeal Carcinoma	Cancer Of Larynx

Intellectual Developmental Disorder, X-Linked 109

Fraxe Syndrome	Fragile Xe Syndrome
Mental Retardation, X-Linked, Fraxe Type	XLID109
Mrx109	Mental Retardation, X-Linked, Associated With Fragile Site Fraxe
Fraxe Mental Retardation Syndrome	X-Linked Intellectual Developmental Disorder 109
Fraxe Intellectual Disability	Fraxe
Mental Retardation, X-Linked 109	Fragile Site On Chromosome Xq28
Fragile Site, Folic Acid Type	X-Linked Intellectual Disability Associated With Fragile Site Fraxe
Fraxe Intellectual Deficit	Intellectual Disability Associated With Fragile Site Fraxe

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160786	TREX1-IN-3	Inhibitor	/	Unkown
HY-160786A	TREX1-IN-4	Inhibitor	/	Unkown
HY-RS15009	TREX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TREX2	MGD	MGI:1346343
Rattus norvegicus	TREX2	RGD	RGD:1562245
Canis familiaris	TREX2	VGNC	VGNC:54379
Felis catus	TREX2	VGNC	VGNC:66523

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