RNF139 - ring finger protein 139 Gene

Homo sapiens

Also known as RCA1; TRC8; HRCA1

Gene ID: 11236 | Gene type: protein coding

About RNF139

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:124,474,880-124,488,618 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 33.6), testis (RPKM 25.9) and 25 other tissues.

Summary

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin Ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid Cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]

RNF139 Products(1)

mRNA	Protein	Name
NM_007218.4	NP_009149.2	E3 ubiquitin-protein ligase RNF139

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protease binding	IPI IPI: Inferred from physical interaction	25239945	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12032852	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	10500182	GOA
enables ubiquitin-like protein transferase activity	IDA IDA: Inferred from direct assay	17016439	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	17016439	GOA
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	19720873	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	25239945	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17016439	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	20068067	GOA
involved in positive regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	25239945	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	25239945	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	10500182	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	19720873	GOA
involved in regulation of ER to Golgi vesicle-mediated transport	IDA IDA: Inferred from direct assay	19706601	GOA
involved in regulation of protein processing	IDA IDA: Inferred from direct assay	19706601	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Derlin-1 retrotranslocation complex	IDA IDA: Inferred from direct assay	25239945	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12032852	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF139 Protein Structure

TRC8_N

zf-RING_2

0
200
400
600
664 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF139

RING-type E3 ubiquitin transferase RNF139

Related Diseases

Diseases

Alias

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Dysgerminoma

Hereditary Renal Cell Carcinoma

Collecting Duct Carcinoma

Kidney Medullary Carcinoma	Renal Medullary Carcinoma
Bdc	Bellini Carcinoma
Bellini Duct Carcinoma	Cdc
Collecting Duct Carcinoma Of The Kidney	Renal Cell Adenocarcinoma
Carcinoma Of Renal Collecting Duct	Renal Carcinoma, Collecting Duct Type
Renal Cell Carcinoma	Bellini'S Duct Carcinoma
Renal Collecting Duct Carcinoma	Adenocarcinoma Of Kidney

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Dysgerminoma Of Ovary

Ovarian Dysgerminoma	Malignant Dysgerminomatous Germ Cell Tumour Of Ovary
Dysgerminoma, Unspecified Site, Female

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12051	RNF139 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RNF139	VGNC	VGNC:84109
Bos taurus	RNF139	VGNC	VGNC:34023
Canis familiaris	RNF139	VGNC	VGNC:45632
Mus musculus	RNF139	MGD	MGI:1923091
Rattus norvegicus	RNF139	RGD	RGD:1306670

Name
Email *

	Sorry, but the email address you supplied was invalid.