CA5B - carbonic anhydrase 5B Gene

Homo sapiens

Also known as CAVB; CA-VB

Gene ID: 11238 | Gene type: protein coding

About CA5B

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,738,270-15,788,411 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 14 paralogues. Broad expression in testis (RPKM 4.8), ovary (RPKM 2.8) and 24 other tissues.

Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes Carbonic Anhydrase 5B. CA5B, and the related CA5A gene, has its expression localized in the mitochondria though CA5B has a wider tissue distribution than CA5A, which is restricted to the liver, kidneys, and skeletal muscle. A Carbonic Anhydrase pseudogene (CA5BP1) is adjacent to the CA5B gene and these two loci produce CA5BP1-CA5B readthrough transcripts. [provided by RefSeq, Jan 2019]

CA5B Products(1)

mRNA	Protein	Name
NM_007220.4	NP_009151.1	carbonic anhydrase 5B, mitochondrial precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables carbonate dehydratase activity	IDA IDA: Inferred from direct assay	10409679	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	10409679	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CA5B Protein Structure

Carb_anhydrase

0
100
200
317 a.a.

Protein Preferred Names

Protein Names

carbonic anhydrase 5B, mitochondrial

carbonate dehydratase VB

Recombinant CA5B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7721	Carbonic Anhydrase 5B Protein, Human (His)	Q9Y2D0 (C34-P317)	≥95%

Related Diseases

Diseases

Alias

Carbonic Anhydrase Va Deficiency

Hyperammonemic Encephalopathy Due To Carbonic Anhydrase Va Deficiency	Ca-Va Deficiency
Hyperammonemia Due To Carbonic Anhydrase Va Deficiency	Mitochondrial Carbonic Anhydrase Va Deficiency
Ca5ad	Carbonic Anhydrase Va Deficiency, Hyperammonemia Due To

Intracranial Hypertension, Idiopathic

Pseudotumor Cerebri	Idiopathic Intracranial Hypertension
Benign Intracranial Hypertension	Iih
Benign Intracran. Hypt.

External Ear Disease

Diseases Of External Ear	Preauricular Cyst
Preauricular Sinus And Fistula	Preauricular Sinus Or Fistula

Enamel Erosion

Otitis Externa

Swimmer'S Ear	Infective Otitis Externa
Acute Infective Otitis Externa

Seborrheic Dermatitis

Seborrhoeic Dermatitis	Seborrhea
Seborrhoeic Eczema	Skin Seborrheic
Dermatitis, Seborrheic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01772	CA5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CA5B	MGD	MGI:1926249
Macaca mulatta	CA5B	VGNC	VGNC:70492
Canis familiaris	CA5B	VGNC	VGNC:38613
Bos taurus	CA5B	VGNC	VGNC:26655
Rattus norvegicus	CA5B	RGD	RGD:1549783
Felis catus	CA5B	VGNC	VGNC:60276
Others	CA5B	NCBI

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