PXMP4 - peroxisomal membrane protein 4 Gene

Homo sapiens

Also known as PMP24

Gene ID: 11264 | Gene type: protein coding

About PXMP4

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:33,702,758-33,720,310 (from NCBI)

This gene has 3 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in lung (RPKM 6.4), thyroid (RPKM 4.6) and 25 other tissues.

Summary

Located in peroxisomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

PXMP4 Products(2)

mRNA	Protein	Name
NM_007238.5	NP_009169.3	peroxisomal membrane protein 4 isoform a
NM_183397.3	NP_899634.1	peroxisomal membrane protein 4 isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14709540	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	14709540	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PXMP4 Protein Structure

Tim17

0
100
200
212 a.a.

Protein Preferred Names

Protein Names

peroxisomal membrane protein 4

24 kDa peroxisomal intrinsic membrane protein

Related Diseases

Diseases

Alias

Alpha-Methylacyl-Coa Racemase Deficiency

Amacr Deficiency

AMACRD

Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders	Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum
Disorders Of Peroxisome Biogenesis	Zellweger Spectrum
Zellweger Syndrome Spectrum	Peroxisomal Biogenesis Disorders
Pbd, Zss	Pbd-Zsd
Pbd-Zss	Pbd-Zellweger Spectrum Disorder
Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum	Peroxisome Biogenesis Disorder
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorders
Zellweger Spectrum Disorder	Hyperpipecolic Acidaemia

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11483	PXMP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PXMP4	VGNC	VGNC:33585
Mus musculus	PXMP4	MGD	MGI:1891701
Macaca mulatta	PXMP4	VGNC	VGNC:97125
Felis catus	PXMP4	VGNC	VGNC:64449
Canis familiaris	PXMP4	VGNC	VGNC:45221
Rattus norvegicus	PXMP4	RGD	RGD:628782

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