PHF21B - PHD finger protein 21B Gene

Homo sapiens

Also known as PHF4; BHC80L

Gene ID: 112885 | Gene type: protein coding

About PHF21B

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:44,881,162-45,010,005 (from NCBI)

This gene has 12 transcripts (splice variants), 173 orthologues and 5 paralogues. Biased expression in testis (RPKM 1.4), brain (RPKM 1.4) and 8 other tissues.

Summary

Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]

PHF21B Products(5)

mRNA	Protein	Name
NM_001135862.3	NP_001129334.1	PHD finger protein 21B isoform 2
NM_001242450.2	NP_001229379.1	PHD finger protein 21B isoform 3
NM_001284296.2	NP_001271225.1	PHD finger protein 21B isoform 4
NM_001413063.1	NP_001399992.1	PHD finger protein 21B isoform 2
NM_138415.5	NP_612424.1	PHD finger protein 21B isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26871637	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHF21B Protein Structure

PHD

0
100
200
300
400
500
531 a.a.

Protein Preferred Names

Protein Names

PHD finger protein 21B

PHD finger protein 4

Related Diseases

Diseases

Alias

Mitochondrial Dna Depletion Syndrome 1

MTDPS1	Mitochondrial Neurogastrointestinal Encephalopathy Syndrome, Tymp-Related
Myoneurogastrointestinal Encephalopathy Syndrome	Polip Syndrome
Mitochondrial Dna Depletion Syndrome, Type 1	Mngie, Tymp-Related
Polyneuropathy, Ophthalmoplegia, Leukoencephalopathy, And Intestinal Pseudoobstruction	Mitochondrial Dna Depletion Syndrome 1, Mngie Type
Mitochondrial Neurogastrointestinal Encephalomyopathy	Mitochondrial Neurogastrointestinal Encephalopathy Syndrome Tymp-Related
Myoneurogastrointestinal Encephalomyopathy	Polyneuropathy Ophthalmoplegia Leukoencephalopathy And Intestinal Pseudoobstruction
Mitochondrial Neurogastrointestinal Encephalopathy Syndrome

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10424	PHF21B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PHF21B	VGNC	VGNC:75861
Rattus norvegicus	PHF21B	RGD	RGD:1308739
Bos taurus	PHF21B	VGNC	VGNC:32822
Canis familiaris	PHF21B	VGNC	VGNC:108212
Mus musculus	PHF21B	MGD	MGI:2443812
Felis catus	PHF21B	VGNC	VGNC:64143

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