ADCY7 - adenylate cyclase 7 Gene

Homo sapiens

Also known as AC7

Gene ID: 113 | Gene type: protein coding

About ADCY7

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,244,699-50,318,135 (from NCBI)

This gene has 16 transcripts (splice variants), 203 orthologues and 17 paralogues. Broad expression in spleen (RPKM 22.5), appendix (RPKM 19.0) and 24 other tissues.

Summary

This gene encodes a membrane-bound Adenylate Cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase Enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]

ADCY7 Products(2)

mRNA	Protein	Name
NM_001114.5	NP_001105.1	adenylate cyclase type 7 isoform 1
NM_001286057.2	NP_001272986.1	adenylate cyclase type 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables adenylate cyclase activity	IDA IDA: Inferred from direct assay	11113152	GOA
enables adenylate cyclase activity	IMP IMP: Inferred from mutant phenotype	18541530	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cAMP biosynthetic process	IDA IDA: Inferred from direct assay	11113152	GOA
involved in cellular response to ethanol	IDA IDA: Inferred from direct assay	12454008	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	11113152	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADCY7 Protein Structure

Guanylate_cyc

DUF1053

Guanylate_cyc

0
200
400
600
800
1000
1080 a.a.

Protein Preferred Names

Protein Names

adenylate cyclase type 7

ATP pyrophosphate-lyase 7

Related Diseases

Diseases

Alias

Leber Congenital Amaurosis 1

LCA1	Amaurosis Congenita Of Leber I
Lca	Retinal Blindness, Congenital
Crb	Leber Congenital Amaurosis Type I
Leber Congenital Amaurosis, Type 1	Amaurosis Congenita Of Leber, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00333	ADCY7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ADCY7	VGNC	VGNC:59620
Macaca mulatta	ADCY7	VGNC	VGNC:69515
Bos taurus	ADCY7	VGNC	VGNC:25648
Mus musculus	ADCY7	MGD	MGI:102891
Rattus norvegicus	ADCY7	RGD	RGD:619966
Canis familiaris	ADCY7	VGNC	VGNC:37624

Name
Email *

	Sorry, but the email address you supplied was invalid.