SLCO2B1 - solute carrier organic anion transporter family member 2B1 Gene

Homo sapiens

Also known as OATPB; OATP-B; OATP2B1; SLC21A9

Gene ID: 11309 | Gene type: protein coding

About SLCO2B1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:75,151,107-75,206,549 (from NCBI)

This gene has 19 transcripts (splice variants), 205 orthologues and 10 paralogues. Broad expression in liver (RPKM 44.0), lung (RPKM 34.3) and 23 other tissues.

Summary

This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated Steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

SLCO2B1 Products(3)

mRNA	Protein	Name
NM_001145211.3	NP_001138683.1	solute carrier organic anion transporter family member 2B1 isoform 2
NM_001145212.3	NP_001138684.1	solute carrier organic anion transporter family member 2B1 isoform 3
NM_007256.5	NP_009187.1	solute carrier organic anion transporter family member 2B1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables organic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	10873595	GOA
enables organic anion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	29871943	GOA
enables prostaglandin transmembrane transporter activity	IDA IDA: Inferred from direct assay	10873595	GOA
enables sodium-independent organic anion transmembrane transporter activity	IDA IDA: Inferred from direct assay	18501590	GOA
enables transmembrane transporter activity	IDA IDA: Inferred from direct assay	25132355	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in organic anion transport	IDA IDA: Inferred from direct assay	12724351	GOA
involved in transmembrane transport	IDA IDA: Inferred from direct assay	12724351	GOA
involved in transmembrane transport	IMP IMP: Inferred from mutant phenotype	29752999	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12724351	GOA
located in basal plasma membrane	IDA IDA: Inferred from direct assay	11159893	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21278488	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLCO2B1 Protein Structure

OATP

0
200
400
600
709 a.a.

Protein Preferred Names

Protein Names

solute carrier organic anion transporter family member 2B1

OATP-RP2

Related Diseases

Diseases

Alias

Bronchiectasis 3

Ileum Cancer

Ileal Neoplasm	Malignant Neoplasm Of Ileum
Ileal Cancer	Ileal Neoplasms

Myasthenic Syndrome, Congenital, 1b, Fast-Channel

CMS1B	Congenital Myasthenic Syndrome 1b
Myasthenic Syndrome, Congenital, Fast-Channel	Congenital Myasthenic Syndrome 1b, Fast-Channel
Fccms	Myasthenic Syndrome, Fast-Channel Congenital
Myasthenic Syndrome, Congenital, Type 1b, Fast-Channel	Congenital Myasthenic Syndrome Ib

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13356	SLCO2B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLCO2B1	RGD	RGD:621391
Macaca mulatta	SLCO2B1	VGNC	VGNC:77603
Mus musculus	SLCO2B1	MGD	MGI:1351872
Bos taurus	SLCO2B1	VGNC	VGNC:34952
Canis familiaris	SLCO2B1	VGNC	VGNC:46496
Felis catus	SLCO2B1	VGNC	VGNC:65445

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