CHRM3 - cholinergic receptor muscarinic 3 Gene

Homo sapiens

Also known as HM3; PBS; EGBRS

Gene ID: 1131 | Gene type: protein coding

About CHRM3

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:239,386,568-239,915,450 (from NCBI)

This gene has 12 transcripts (splice variants), 257 orthologues, 25 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 5.0), salivary gland (RPKM 2.4) and 12 other tissues.

Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as Adenylate Cyclase inhibition, phosphoinositide degeneration, and Potassium Channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

CHRM3 Products(10)

mRNA	Protein	Name
NM_000740.4	NP_000731.1	muscarinic acetylcholine receptor M3
NM_001347716.2	NP_001334645.1	muscarinic acetylcholine receptor M3
NM_001375978.1	NP_001362907.1	muscarinic acetylcholine receptor M3
NM_001375979.1	NP_001362908.1	muscarinic acetylcholine receptor M3
NM_001375980.1	NP_001362909.1	muscarinic acetylcholine receptor M3
NM_001375981.1	NP_001362910.1	muscarinic acetylcholine receptor M3
NM_001375982.1	NP_001362911.1	muscarinic acetylcholine receptor M3
NM_001375983.1	NP_001362912.1	muscarinic acetylcholine receptor M3
NM_001375984.1	NP_001362913.1	muscarinic acetylcholine receptor M3
NM_001375985.1	NP_001362914.1	muscarinic acetylcholine receptor M3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19575010	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in acetylcholine receptor signaling pathway	IDA IDA: Inferred from direct assay	17478539	GOA
acts upstream of or within calcium-mediated signaling	IDA IDA: Inferred from direct assay	17478539	GOA
acts upstream of or within regulation of monoatomic ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	17478539	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	17478539	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21056967	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHRM3 Protein Structure

7tm_1

0
100
200
300
400
500
590 a.a.

Protein Preferred Names

Protein Names

muscarinic acetylcholine receptor M3

acetylcholine receptor, muscarinic 3

CHRM3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CHRM3	P20309	CHRM5	Homo sapiens	P08912	BRET	20398705

Cross: Cross-species interaction Intra: Intraspecies interaction

CHRM3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81142	Muscarinic Acetylcholine receptor M3 Antibody	WB	Human

Related Diseases

Diseases

Alias

Prune Belly Syndrome

Eagle-Barrett Syndrome	Abdominal Muscle Deficiency Syndrome
PBS	Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism
Egbrs	Eagle-Barret Syndrome
Urethral Obstruction Sequence	Obrinsky Syndrome
Triad Syndrome	Obrisnksy Syndrome
Euos	Early Urethral Obstruction Sequence
Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction	Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism
Abdomen Muscle Deficiency Syndrome	Abdomen Muscular Deficiency Syndrome
Abdominal Muscular Deficiency Syndrome	Abdominal Muscle Aplasia Syndrome

Low Compliance Bladder

Overactive Bladder	Hyperactivity Of Bladder
Hypertonic Bladder	Hypertonicity Of Bladder
Low Bladder Compliance	Oab - [Overactive Bladder]

Sjogren Syndrome

Sicca Syndrome	Sjogren'S Syndrome
Sjögren Syndrome	Sjogren-Gougerot Syndrome
Keratoconjunctivitis Sicca	Sjögren'S Syndrome
Xerodermosteosis	Dacryosialoadenopathia Atrophicans
Gougerot-Houwer-Sjogren Syndrome	Gougerot-Sjogren Syndrome
Keratoconjunctivitis Sicca-Xerostomia	Secreto-Inhibitor-Xerodermostenosis
Primary Sjogren Syndrome	Primary Sjogren-Gougerot Syndrome
Sjogrens Syndrome Primary	Sjogrens Syndrome
Dry Eye Syndromes

Cholinergic Urticaria

Aplasia Of Lacrimal And Salivary Glands

ALSG	Congenital Absence Of Lacrimal Puncta And Salivary Glands
Xerostomia	Absence Of Salivary Glands
Parotid Aplasia Or Hypoplasia	Congenital Absence Of Lacrimal Puncta Or Salivary Glands
Alsg - [Aplasia Of Lacrimal Or Salivary Glands]

Urofacial Syndrome 1

Urofacial Syndrome	Ochoa Syndrome
Hydronephrosis With Peculiar Facial Expression	Ufs
Inverted Smile And Occult Neuropathic Bladder	Partial Facial Palsy With Urinary Abnormalities
UFS1	Urofacial Ochoa'S Syndrome
Urofacial Syndrome Type 1	Facial Palsy, Partial, With Urinary Abnormalities
Hydronephrosis-Inverted Smile	Inverted Smile-Neurogenic Bladder
Hydronephrosis-Inverted Smile Syndrome	Inverted Smile-Neurogenic Bladder Syndrome
Partial Facial Palsy Partial With Urinary Abnormalities	Urologic Diseases

Physical Urticaria

Symptomatic Dermographism

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease	COPD
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset	Chronic Obstructive Lung Disease
Chronic Obstructive Airway Disease	Pulmonary Disease, Chronic Obstructive, Susceptibility To
Cold	Severe Early-Onset Chronic Obstructive Pulmonary Disease
Pulmonary Disease Chronic Obstructive	Pulmonary Disease, Obstructive, Chronic, Susceptibility To
Chronic Obstructive Pulmonary Disease Of Horses	Common Cold
Upper Respiratory Infections	Copd - [Chronic Obstructive Pulmonary Disease]
Coad - [Chronic Obstructive Airways Disease]	Cold - [Chronic Obstructive Lung Disease]
Chronic Airway Disease Nos	Chronic Airways Limitation, Unspecified
Chronic Obstructed Airway, Unspecified	Chronic Obstructive Airway Disease, Unspecified
Chronic Obstructive Airway, Unspecified	Obstructive Lung Disease Nos
Chronic Obstructive Lung Disease Nos	Chronic Obstructive Lung Nos
Obstructive Pulmonary Disease Nos	Exacerbation Copd Nos
Acute Exacerbation Copd

Functional Colonic Disease

Colonic Diseases, Functional

Colonic Pseudo-Obstruction

Primary Chronic Pseudo-Obstruction Of Colon

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02662	CHRM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CHRM3	VGNC	VGNC:27320
Canis familiaris	CHRM3	VGNC	VGNC:39233
Mus musculus	CHRM3	MGD	MGI:88398
Felis catus	CHRM3	VGNC	VGNC:60875
Rattus norvegicus	CHRM3	RGD	RGD:2343
Macaca mulatta	CHRM3	VGNC	VGNC:71043

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