2. Gene
  3. CHRM4 - cholinergic receptor muscarinic 4 Gene

CHRM4 - cholinergic receptor muscarinic 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HM4; M4R

Gene ID: 1132 | Gene type: protein coding

About CHRM4

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,383,789-46,391,776 (from NCBI)

This gene has 2 transcripts (splice variants), 187 orthologues and 25 paralogues.

Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as Adenylate Cyclase inhibition, phosphoinositide degeneration, and Potassium Channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]

CHRM4 Products(2)

mRNA Protein Name
NM_000741.5 NP_000732.2 muscarinic acetylcholine receptor M4
NM_001366692.2 NP_001353621.1 muscarinic acetylcholine receptor M4

CHRM4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (49 - 453)

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  • 479 a.a.
Protein Preferred Names Protein Names

muscarinic acetylcholine receptor M4

acetylcholine receptor, muscarinic 4

Related Diseases

Diseases Alias
Cardiomyopathy, Familial Hypertrophic, 11

Hypertrophic Cardiomyopathy 11

CMH11

Cardiomyopathy, Hypertrophic, 11

Cardiomyopathy Familial Hypertrophic 11

Cardiomyopathy, Familial Hypertrophic 11

Cardiomyopathy, Hypertrophic, Familial, Type 11
Spherocytosis, Type 3

Hereditary Spherocytosis Type 3

SPH3

Hs3

Spherocytosis, Hereditary, 3

Hereditary Spherocytosis 3

Spherocytosis 3
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02663 CHRM4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CHRM4 VGNC VGNC:60876
Mus musculus CHRM4 MGD MGI:88399
Bos taurus CHRM4 VGNC VGNC:54862
Rattus norvegicus CHRM4 RGD RGD:2344
Canis familiaris CHRM4 VGNC VGNC:39234
Macaca mulatta CHRM4 VGNC VGNC:100913