ADPRHL1 - ADP-ribosylhydrolase like 1 Gene

Homo sapiens

Also known as ARH2

Gene ID: 113622 | Gene type: protein coding

About ADPRHL1

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,399,610-113,453,488 (from NCBI)

This gene has 5 transcripts (splice variants), 158 orthologues and 1 paralogue. Biased expression in heart (RPKM 98.4) and prostate (RPKM 3.2).

Summary

ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed 12070318]).[supplied by OMIM, Mar 2008]

ADPRHL1 Products(5)

mRNA	Protein	Name
NM_001304433.1	NP_001291362.1	inactive ADP-ribosyltransferase ARH2 isoform 3
NM_001375393.1	NP_001362322.1	inactive ADP-ribosyltransferase ARH2 isoform 3
NM_001394807.1	NP_001381736.1	inactive ADP-ribosyltransferase ARH2 isoform 4
NM_138430.5	NP_612439.2	inactive ADP-ribosyltransferase ARH2 isoform 1
NM_199162.3	NP_954631.1	inactive ADP-ribosyltransferase ARH2 isoform 2

ADPRHL1 Protein Structure

ADP_ribosyl_GH

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

inactive ADP-ribosyltransferase ARH2

ADP-ribosyl-hydrolase

Related Diseases

Diseases

Alias

Brain Small Vessel Disease 2

Porencephaly 2	BSVD2
Gould Syndrome 2	Porencephaly 2, Formerly
Poren2, Formerly	Poren2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00405	ADPRHL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADPRHL1	MGD	MGI:2442168
Rattus norvegicus	ADPRHL1	RGD	RGD:1305641

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