2. Gene
  3. Acsl4 - acyl-CoA synthetase long-chain family member 4 Gene

Acsl4 - acyl-CoA synthetase long-chain family member 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Acs4; Facl4

Gene ID: 113976 | Gene type: protein coding

About Acsl4

Summary

Enables arachidonate-CoA Ligase activity. Involved in several processes, including dendritic spine development; long-chain fatty-acyl-CoA biosynthetic process; and positive regulation of Insulin secretion. Located in mitochondrial membrane; neuronal cell body; and peroxisome. Colocalizes with endoplasmic reticulum. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Acsl4 Products(1)

mRNA Protein Name
NM_053623.1 NP_446075.1 long-chain-fatty-acid--CoA ligase 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables arachidonate-CoA ligase activity IDA
IDA: Inferred from direct assay
28209804 RGD
enables long-chain fatty acid-CoA ligase activity IDA
IDA: Inferred from direct assay
9096315 RGD
enables long-chain fatty acid-CoA ligase activity IMP
IMP: Inferred from mutant phenotype
23766516 RGD
Biological Process GO Annotation Evidence Reference Source
involved in dendritic spine development IMP
IMP: Inferred from mutant phenotype
19166906 RGD
involved in fatty acid metabolic process IDA
IDA: Inferred from direct assay
9096315 RGD
involved in fatty acid transport IGI
IGI: Inferred from genetic interaction
16466685 RGD
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
28209804 RGD
involved in long-chain fatty-acyl-CoA biosynthetic process IGI
IGI: Inferred from genetic interaction
16466685 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
23766516 RGD
involved in response to interleukin-15 IEP
IEP: Inferred from expression pattern
18239634 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
16772660 RGD
involved in triglyceride biosynthetic process IGI
IGI: Inferred from genetic interaction
16466685 RGD
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
12147264 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
19166906 RGD
located in peroxisome IDA
IDA: Inferred from direct assay
12147264 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

long-chain-fatty-acid--CoA ligase 4

LACS 4

arachidonate--CoA ligase

fatty acid-Coenzyme A ligase, long chain 4

long-chain acyl-CoA synthetase 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16244 Acsl4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00202 ACSL4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-155851 Lepadin E / Unkown
HY-155852 Lepadin H Inducer / Unkown
HY-115701 1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acsl4 NCBI NCBI:2182