ERMAP - erythroblast membrane associated protein (Scianna blood group) Gene

Homo sapiens

Also known as RD; SC; BTN5; PRO2801

Gene ID: 114625 | Gene type: protein coding

About ERMAP

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:42,817,122-42,844,991 (from NCBI)

This gene has 9 transcripts (splice variants), 99 orthologues, 15 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 13.2), thyroid (RPKM 8.4) and 25 other tissues.

Summary

The protein encoded by this gene is a cell surface transmembrane protein that may act as an erythroid cell receptor, possibly as a mediator of cell adhesion. Polymorphisms in this gene are responsible for the Scianna/Radin blood group system. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ERMAP Products(2)

mRNA	Protein	Name
NM_001017922.2	NP_001017922.1	erythroid membrane-associated protein precursor
NM_018538.4	NP_061008.2	erythroid membrane-associated protein precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11549310	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERMAP Protein Structure

V-set

PRY

SPRY

0
100
200
300
400
475 a.a.

Protein Preferred Names

Protein Names

erythroid membrane-associated protein

Radin blood group (Rd)

ERMAP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ERMAP	Q96PL5	TMEM14A	Homo sapiens	Q9Y6G1	Validated Y2H	32296183
Intra	ERMAP	Q96PL5	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	ERMAP	Q96PL5	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	ERMAP	Q96PL5	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ERMAP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70896	ERMAP Protein, Human (HEK293, His)	Q96PL5 (H30-A155)	≥95%

Related Diseases

Diseases

Alias

Radin Blood Group Antigen

RD	Blood Group--Radin Antigen

Scarlet Fever

Scarlatina

Scarlatina Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04503	ERMAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ERMAP	VGNC	VGNC:99910
Felis catus	ERMAP	VGNC	VGNC:80201
Mus musculus	ERMAP	MGD	MGI:1349816
Rattus norvegicus	ERMAP	RGD	RGD:1309996
Others	ERMAP	NCBI

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