PGLYRP2 - peptidoglycan recognition protein 2 Gene

Homo sapiens

Also known as tagL; PGRPL; PGRP-L; PGLYRPL; HMFT0141; TAGL-like; tagl-beta; tagL-alpha

Gene ID: 114770 | Gene type: protein coding

About PGLYRP2

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,468,645-15,479,501 (from NCBI)

This gene has 4 transcripts (splice variants), 274 orthologues and 3 paralogues. Restricted expression toward liver (RPKM 52.9).

Summary

This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in Bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]

PGLYRP2 Products(2)

mRNA	Protein	Name
NM_001363546.1	NP_001350475.1	N-acetylmuramoyl-L-alanine amidase isoform 2 precursor
NM_052890.4	NP_443122.3	N-acetylmuramoyl-L-alanine amidase isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables N-acetylmuramoyl-L-alanine amidase activity	IDA IDA: Inferred from direct assay	14506276	GOA
enables peptidoglycan binding	IDA IDA: Inferred from direct assay	11461926	GOA
enables peptidoglycan immune receptor activity	IDA IDA: Inferred from direct assay	11461926	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	11461926	GOA
involved in detection of bacterium	IDA IDA: Inferred from direct assay	11461926	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGLYRP2 Protein Structure

Amidase_2

0
100
200
300
400
500
576 a.a.

Protein Preferred Names

Protein Names

N-acetylmuramoyl-L-alanine amidase

peptidoglycan recognition protein L

Recombinant PGLYRP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71844	PGLYRP2/PGRP-L Protein, Human (P.pastoris, His)	Q96PD5-1 (S22-Q576)	≥95%

Related Diseases

Diseases

Alias

Cicatricial Entropion

Febrile Seizures, Familial, 4

FEB4	Convulsions, Familial Febrile, 4
Familial Febrile Seizures 4	Familial Febrile Convulsions 4

Meester-Loeys Syndrome

MRLS

Familial Febrile Seizures

Familial Febrile Convulsions	Feb
Febrile Seizures, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10388	PGLYRP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PGLYRP2	VGNC	VGNC:75887
Canis familiaris	PGLYRP2	VGNC	VGNC:44462
Mus musculus	PGLYRP2	MGD	MGI:1928099
Bos taurus	PGLYRP2	VGNC	VGNC:32792
Rattus norvegicus	PGLYRP2	RGD	RGD:1359183
Felis catus	PGLYRP2	VGNC	VGNC:64123
Others	PGLYRP2	NCBI

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