SLITRK1 - SLIT and NTRK like family member 1 Gene

Homo sapiens

Also known as TTM; LRRC12

Gene ID: 114798 | Gene type: protein coding

About SLITRK1

Cytogenetic location: 13q31.1 Genomic coordinates (GRCh38): 13:83,877,205-83,882,474 (from NCBI)

This gene has 2 transcripts (splice variants), 187 orthologues, 25 paralogues and is associated with 3 phenotypes. Restricted expression toward brain (RPKM 10.6).

Summary

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with Trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

SLITRK1 Products(2)

mRNA	Protein	Name
NM_001281503.2	NP_001268432.1	SLIT and NTRK-like protein 1 precursor
NM_052910.2	NP_443142.1	SLIT and NTRK-like protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19640509	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	23990902	GOA
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	23345436	GOA
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	23345436	GOA
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	27273464	GOA
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	23345436	GOA
involved in synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	23345436	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	23345436	GOA
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	23345436	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23345436	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	23345436	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLITRK1 Protein Structure

LRR_8

LRR_1

LRR_8

0
200
400
600
696 a.a.

Protein Preferred Names

Protein Names

SLIT and NTRK-like protein 1

leucine-rich repeat-containing protein 12

SLITRK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLITRK1	Q96PX8	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	SLITRK1	Q96PX8	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	SLITRK1	Q96PX8	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLITRK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76077	SLITRK1 Protein, Human (HEK293, His-Fc)	Q96PX8 (N18-S616)	≥95%
HY-P76078	SLITRK1 Protein, Human (HEK293, His)	Q96PX8 (N18-S616)	≥95%

Related Diseases

Diseases

Alias

Trichotillomania

TTM	Hair-Pulling Syndrome
Compulsive Hair Plucking	Hair Pulling Disorder

Gilles De La Tourette Syndrome

Tourette Syndrome	Tourette Disorder
GTS	Ts
Gilles De La Tourette'S Syndrome	Motor-Verbal Tic Disorder
Guinon'S Disease	Psychogenic Tics
Tourette'S Syndrome	Chronic Motor And Vocal Tic Disorder
Td	Tourette'S Disease
Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]	Combined Vocal And Multiple Motor Tic Disorder
Tic De La Tourette

Obsessive-Compulsive Disorder

OCD	Obsessive-Compulsive Disorder, Susceptibility To
Anancastic Neurosis	Obsessive Compulsive Disorder
Anankastic Neurosis	Obsessive-Compulsive Neurosis
Obsessive Compulsive Behavior

Chronic Tic Disorder

Chronic Motor Or Vocal Tic Disorder	Tic Disorders
Tic Disorder	Tic Disorder Nos
Tic Nos	Tic Spasm Nos

Transient Tic Disorder

Tic Disorder

Tics	Behavioral Tic

Color Agnosia

Deafness, Autosomal Dominant 33

DFNA33	Autosomal Dominant Nonsyndromic Deafness 33
Autosomal Dominant Deafness 33

Trichothiodystrophy 5, Nonphotosensitive

TTD5	Nonphotosensitive Trichothiodystrophy 5
Trichothiodystrophy 5, Non-Photosensitive

Impulse Control Disorder

Disruptive, Impulse Control, And Conduct Disorders

Abcd Syndrome

ABCDS	Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut, And Deafness
Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut And Deafness

Echolalia

Stereotypic Movement Disorder

Stereotypy Habit Disorder	Stereotyped Repetitive Movements
Stereotyped Disorder	Stereotypes Nos
Stereotype Habit Disorder

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13373	SLITRK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLITRK1	VGNC	VGNC:65454
Rattus norvegicus	SLITRK1	RGD	RGD:1308858
Mus musculus	SLITRK1	MGD	MGI:2679446
Bos taurus	SLITRK1	VGNC	VGNC:34962
Canis familiaris	SLITRK1	VGNC	VGNC:46506
Macaca mulatta	SLITRK1	VGNC	VGNC:77744
Others	SLITRK1	NCBI

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