1. Gene
  2. UBQLN2 - ubiquilin 2 Gene

UBQLN2 - ubiquilin 2 Gene

Homo sapiens

Also known as DSK2; ALS15; CHAP1; N4BP4; PLIC2; HRIHFB2157

Gene ID: 29978 | Gene type: protein coding

About UBQLN2

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:56,563,627-56,567,868 (from NCBI)

This gene has 1 transcript (splice variant), 86 orthologues, 5 paralogues and is associated with 2 phenotypes.

Summary

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the Proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]

UBQLN2 Products(1)

mRNA Protein Name
NM_013444.4 NP_038472.2 ubiquilin-2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
29526694 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15231748 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
24215460 GOA
involved in negative regulation of G protein-coupled receptor internalization IMP
IMP: Inferred from mutant phenotype
18199683 GOA
involved in negative regulation of clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
18199683 GOA
involved in positive regulation of ERAD pathway IMP
IMP: Inferred from mutant phenotype
18307982 GOA
involved in regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
20529957 GOA
involved in regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
20529957 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18199683 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBQLN2 Protein Structure

ubiquitin

ubiquitin: Ubiquitin family (38 - 104)

UBA

UBA: UBA/TS-N domain (583 - 618)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 624 a.a.
Protein Preferred Names Protein Names

ubiquilin-2

Nedd4 binding protein 4

UBQLN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UBQLN2 Q9UHD9 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 KRTAP12-1 Homo sapiens P59990
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 KRTAP12-1 Homo sapiens P59990
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 DEFA6 Homo sapiens Q01524
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 DEFA6 Homo sapiens Q01524
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 HEMK1 Homo sapiens Q9Y5R4
Validated Y2H
32296183
Intra
UBQLN2 Q9UHD9 TIMP2 Homo sapiens P16035
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 TIMP2 Homo sapiens P16035
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 CST4 Homo sapiens P01036
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 PNMA3 Homo sapiens Q9UL41
Validated Y2H
32296183
Intra
UBQLN2 Q9UHD9 IFNA13 Homo sapiens P01562
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 IFNA13 Homo sapiens P01562
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 VWC2 Homo sapiens Q2TAL6
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 VWC2 Homo sapiens Q2TAL6
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 WFDC12 Homo sapiens Q8WWY7
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 WFDC12 Homo sapiens Q8WWY7
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 RBFOX2 Homo sapiens O43251-10
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 RBFOX2 Homo sapiens O43251-10
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 PSORS1C2 Homo sapiens Q9UIG4
Validated Y2H
32296183
Intra
UBQLN2 Q9UHD9 C6orf15 Homo sapiens Q6UXA7
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 C6orf15 Homo sapiens Q6UXA7
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 CLPSL2 Homo sapiens Q6UWE3
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 CLPSL2 Homo sapiens Q6UWE3
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 TNFRSF18 Homo sapiens Q9Y5U5-2
Validated Y2H
32296183
Intra
UBQLN2 Q9UHD9 PCDHGA9 Homo sapiens Q9Y5G4-2
Validated Y2H
32296183
Intra
UBQLN2 Q9UHD9 GALP Homo sapiens Q9UBC7
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 GALP Homo sapiens Q9UBC7
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 SFTPA2 Homo sapiens Q8IWL1
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 SFTPA2 Homo sapiens Q8IWL1
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 LY6G6D Homo sapiens O95868
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 LY6G6D Homo sapiens O95868
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 NPBWR1 Homo sapiens P48145
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 NPBWR1 Homo sapiens P48145
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 NRN1L Homo sapiens Q496H8
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 NRN1L Homo sapiens Q496H8
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 PMEPA1 Homo sapiens Q969W9-2
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 PMEPA1 Homo sapiens Q969W9-2
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 CSN2 Homo sapiens P05814
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 CSN2 Homo sapiens P05814
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 ANKRD33 Homo sapiens Q7Z3H0-1
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 ANKRD33 Homo sapiens Q7Z3H0-1
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 SMIM19 Homo sapiens Q96E16
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 SMIM19 Homo sapiens Q96E16
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 LATS1 Homo sapiens O95835-2
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 LATS1 Homo sapiens O95835-2
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 OPN4 Homo sapiens Q9UHM6
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 OPN4 Homo sapiens Q9UHM6
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 OPN4 Homo sapiens Q9UHM6
Validated Y2H
32296183
Intra
UBQLN2 Q9UHD9 APOC4 Homo sapiens P55056
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 APOC4 Homo sapiens P55056
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 PRAP1 Homo sapiens Q96NZ9
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 PRAP1 Homo sapiens Q96NZ9
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 KISS1 Homo sapiens Q15726
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 KISS1 Homo sapiens Q15726
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 COL17A1 Homo sapiens Q9UMD9
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 COL17A1 Homo sapiens Q9UMD9
Validated Y2H
32296183
Intra
UBQLN2 Q9UHD9 COL17A1 Homo sapiens Q9UMD9
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 JPH4 Homo sapiens Q96JJ6
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 JPH4 Homo sapiens Q96JJ6
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 HNRNPU Homo sapiens Q00839
Pull Down
25616961
Intra
UBQLN2 Q9UHD9 HNRNPU Homo sapiens Q00839
Y2H
25616961
Intra
UBQLN2 Q9UHD9 HNRNPA1 Homo sapiens P09651
Pull Down
25616961
Intra
UBQLN2 Q9UHD9 HNRNPA1 Homo sapiens P09651
Anti Tag CoIP
25616961
Intra
UBQLN2 Q9UHD9 HNRNPA1 Homo sapiens P09651-2
Y2H
25616961
Intra
UBQLN2 Q9UHD9 HNRNPA1 Homo sapiens P09651-2
Anti Tag CoIP
25616961
Intra
UBQLN2 Q9UHD9 PSMD2 Homo sapiens Q13200
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 PSMD2 Homo sapiens Q13200
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 STAM2 Homo sapiens O75886
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 STAM2 Homo sapiens O75886
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 NPY Homo sapiens P01303
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 NPY Homo sapiens P01303
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 AGR3 Homo sapiens Q8TD06
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 AGR3 Homo sapiens Q8TD06
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 CLEC11A Homo sapiens Q9Y240
Validated Y2H
32296183
Intra
UBQLN2 Q9UHD9 MINPP1 Homo sapiens Q9UNW1
Validated Y2H
32296183
Intra
UBQLN2 Q9UHD9 BCL2L11 Homo sapiens O43521
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 BCL2L11 Homo sapiens O43521
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 MBL2 Homo sapiens P11226
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 MBL2 Homo sapiens P11226
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 ATXN10 Homo sapiens Q9UBB4
Y2H Pooling
32814053
Intra
UBQLN2 Q9UHD9 ATXN10 Homo sapiens Q9UBB4
Validated Y2H
32814053
Intra
UBQLN2 Q9UHD9 ATXN10 Homo sapiens Q9UBB4
Y2H Array
32814053
Intra
UBQLN2 Q9UHD9 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
UBQLN2 Q9UHD9 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 MDK Homo sapiens P21741
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 MDK Homo sapiens P21741
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 PRR4 Homo sapiens Q16378
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 PRR4 Homo sapiens Q16378
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 NOL3 Homo sapiens O60936
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 NOL3 Homo sapiens O60936
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
UBQLN2 Q9UHD9 RAD23A Homo sapiens P54725
Anti Bait CoIP
17098253
Intra
UBQLN2 Q9UHD9 GPX7 Homo sapiens Q96SL4
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 GPX7 Homo sapiens Q96SL4
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 ASPA Homo sapiens P45381
Validated Y2H
32814053
Intra
UBQLN2 Q9UHD9 ASPA Homo sapiens P45381
Y2H Array
32814053
Intra
UBQLN2 Q9UHD9 ASPA Homo sapiens P45381
Y2H Pooling
32814053
Intra
UBQLN2 Q9UHD9 ITPKB Homo sapiens P27987
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 RNF208 Homo sapiens Q9H0X6
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 RNF208 Homo sapiens Q9H0X6
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 ADRM1 Homo sapiens Q16186
Pull Down
20059542
Intra
UBQLN2 Q9UHD9 ECM1 Homo sapiens Q16610
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 ECM1 Homo sapiens Q16610
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 PTGDS Homo sapiens P41222
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 PTGDS Homo sapiens P41222
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 ERP27 Homo sapiens Q96DN0
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 ERP27 Homo sapiens Q96DN0
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 ZG16B Homo sapiens Q96DA0
Y2H Array
32296183
Intra
UBQLN2 Q9UHD9 ZG16B Homo sapiens Q96DA0
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 ASCL1 Homo sapiens P50553
Y2H Prey Pooling
32296183
Intra
UBQLN2 Q9UHD9 ASCL1 Homo sapiens P50553
Y2H Array
32296183
Cross
UBQLN2 Q9UHD9 RPN13 Arabidopsis thaliana O48726
Pull Down
20059542
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 15 With Or Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia

ALS15

Sclerosis, Lateral, Amyotrophic, Type 15, With/Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis Type 15

Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia

Als15

Amyotrophic Lateral Sclerosis 15

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia

Lateral Sclerosis

Primary Lateral Sclerosis

Adult-Onset Primary Lateral Sclerosis

Adult-Onset Pls

Motor Neuron Disease

Pls

Pls - [Primary Lateral Sclerosis]

Lateral Spinal Sclerosis

Lateral Complete Paralysis

Lateral Incomplete Paralysis

Lateral Paralysis

Amyotrophic Lateral Sclerosis 18

Amyotrophic Lateral Sclerosis Type 18

ALS18

Sclerosis, Lateral, Amyotrophic, Type 18

Dementia

Dementias

Presenile Dementia

Alzheimer Type Dementia

Alzheimer Sclerosis

Alzheimer Disease Dementia

Alzheimer Dementia

Primary Degenerative Alzheimer Type Dementia

End Stage Alzheimer'S Dementia

Alzheimer'S Type Atypical Dementia

Alzheimer Type Presenile Dementia

Early Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 2

Dementia In Alzheimer Disease With Early Onset

Early Onset Alzheimer Type Dementia, Uncomplicated

Primary Degenerative Alzheimer Type Dementia, Early Onset

Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated

Alzheimer Disease Dementia With Early Onset

Presenile Sclerosis

Presenile Brain Sclerosis

Presenile Alzheimer Brain Sclerosis

Late Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 1

Dementia In Alzheimer Disease With Late Onset

Primary Degenerative Alzheimer Type Dementia, Late Onset

Sdat - [Senile Dementia, Alzheimer Type]

Alzheimer Disease Dementia With Late Onset

Late Onset Alzheimer Brain Sclerosis

Senile Alzheimer Brain Disease

Senile Alzheimer Brain Sclerosis

Senile Primary Degenerative Alzheimer Type Dementia

Senile Dementia Of The Alzheimer Type

Arteriosclerotic Dementia

Strategic-Infarct Dementia

Post Stroke Dementia

Vascular Cognitive Impairment

Vascular Dementia

Dementia Of The Lewy Body Type

Dementia With Lewy Bodies

Sdlt - [Senile Dementia Of The Lewy Body Type]

Senile Dementia Of The Lewy Body Type

Alcohol-Related Dementia

Alcoholic Dementia Nos

Alcohol-Induced Dementia

Alcoholic Brain Syndrome

Chronic Alcoholic Brain Syndrome

Alcohol Dementia

Late Onset Alcoholic Psychosis

Residual And Late-Onset Alcohol-Induced Psychotic Disorder

Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder

Late-Onset Psychoactive Substance-Induced Psychotic Disorder

Inhalant Dementia

Volatile Solvents Dementia

Dementia In Paralysis Agitans

Pdd - [Parkinson Disease Dementia]

Dementia Syndrome Of Parkinson Disease

Dementia In Parkinson Disease

Parkinson Related Dementia

Dementia In Huntington Chorea

Hiv - [Human Immunodeficiency Virus] Dementia

Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex

Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex

Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex

Aids Related Dementia

Dementia Due To Niacin Deficiency

Amyotrophic Lateral Sclerosis 16, Juvenile

Amyotrophic Lateral Sclerosis Type 16

ALS16

Amyotrophic Lateral Sclerosis 16

Sclerosis, Lateral, Amyotrophic, Type 16, Juvenile

Amyotrophic Lateral Sclerosis 19

Amyotrophic Lateral Sclerosis Type 19

ALS19

Sclerosis, Lateral, Amyotrophic, Type 19

Amyotrophic Lateral Sclerosis Type 14

Als14

Amyotrophic Lateral Sclerosis 14

Amyotrophic Lateral Sclerosis, With Or Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis 14 With Or Without Frontotemporal Dementia

Spinocerebellar Ataxia 2

Spinocerebellar Ataxia Type 2

SCA2

Amyotrophic Lateral Sclerosis 13

Spinocerebellar Degeneration With Slow Eye Movements

SDSEM

Spinocerebellar Atrophy Ii

Olivopontocerebellar Atrophy Ii

Opca2

Cerebellar Degeneration With Slow Eye Movements

Wadia-Swami Syndrome

Amyotrophic Lateral Sclerosis Type 13

ALS13

Olivopontocerebellar Atrophy Holguin Type

Spinocerebellar Ataxia Cuban Type

Olivopontocerebellar Atrophy, Holguin Type

Spinocerebellar Ataxia, Cuban Type

Amyotrophic Lateral Sclerosis, Susceptibility To, 13

Olivopontocerebellar Atrophy 2

Sca 2

Spinocerebellar Ataxia With Slow Eye Movements

Spinocerebellar Atrophy 2

Wadia Swami Syndrome

Opca Ii

Spinocerebellar Ataxia-2

Ataxia, Spinocerebellar, Type 2

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1

Frontotemporal Dementia And/Or Motor Neuron Disease

Ftdmnd

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

Alsftd

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

Frontotemporal Dementia With Motor Neuron Disease

Ftdals

Ftd-Als

Ftd-Mnd

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

Frontotemporal Lobar Degeneration

Grn-Related Frontotemporal Dementia

Amyotrophic Lateral Sclerosis 20

Amyotrophic Lateral Sclerosis Type 20

ALS20

Sclerosis, Lateral, Amyotrophic, Type 20

Multisystem Proteinopathy
Amyotrophic Lateral Sclerosis Type 22

Als 22

Amyotrohpic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis 22

Brown-Vialetto-Van Laere Syndrome
Progressive Muscular Atrophy

Progressive Spinal Muscular Atrophy

Pure Progressive Muscular Atrophy

Pma

Hereditary Spinal Muscle Atrophy

Pma - [Progressive Muscular Atrophy]

Progressive Muscle Atrophy

Progressive Spinal Muscle Atrophy

Duchenne-Aran Atrophy

Duchenne-Aran Muscle Atrophy

Hereditary Sma - [Spinal Muscle Atrophy]

Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia

Pagetoid Amyotrophic Lateral Sclerosis

Pagetoid Neuroskeletal Syndrome

Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia

Multisystem Proteinopathy

Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone

Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement

Lower Motor Neuron Degeneration With Paget-Like Bone Disease

Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone

Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Amyotrophic Lateral Sclerosis Type 12

Amyotrophic Lateral Sclerosis 12

Als12

Sclerosis, Lateral, Amyotrophic, Type Type 12

Paget'S Disease Of Bone

Osteitis Deformans

Paget Disease Of Bone

Osseous Paget'S Disease

Paget Disease Of Bone, Familial

Bone Paget Disease

Familial Paget'S Disease Of Bone

Paget'S Bone Disease

Familial Paget Disease Of Bone

Paget Disease, Bone

Pdb

Pagets Bone Disease

Amyotrophic Lateral Sclerosis Type 6

Amyotrophic Lateral Sclerosis 6, Autosomal Recessive

Als6

Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia

Autosomal Recessive Amyotrophic Lateral Sclerosis 6

Sclerosis, Lateral, Amyotrophic, Type Type 6

Amyotrophic Lateral Sclerosis 6

Progressive Bulbar Palsy

Bulbar Palsy, Progressive

Progressive Bulbar Atrophy

Bulbar Palsy

Pbp - [Progressive Bulbar Palsy]

Progressive Bulbar Paralysis

Bulbar Paralysis

Chronic Bulbar Palsy

Chronic Bulbar Paralysis

Supranuclear Bulbar Paralysis

Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis Type 10

ALS10

Amyotrophic Lateral Sclerosis 10, With Or Without Ftd

Frontotemporal Lobar Degeneration, Tardbp-Related

Amyotrophic Lateral Sclerosis 10

Amyotrophic Lateral Sclerosis 10, With Or Without Frontotemporal Dementia

Tardbp-Related Frontotemporal Lobar Degeneration With Tdp43 Inclusions

Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia And With Tdp43 Inclusions

Sclerosis, Lateral, Amyotrophic, Type Type 10

Giant Axonal Neuropathy 2
Perry Syndrome

Parkinsonism With Alveolar Hypoventilation And Mental Depression

PERRYS

Amyotrophic Lateral Sclerosis 8

Amyotrophic Lateral Sclerosis Type 8

ALS8

Sclerosis, Lateral, Amyotrophic, Type Type 8

Amyotrophic Lateral Sclerosis 4, Juvenile

Amyotrophic Lateral Sclerosis Type 4

ALS4

Amyotrophic Lateral Sclerosis 4

Dhmn With Upper Motor Neuron Signs

Distal Hereditary Motor Neuropathy With Upper Motor Neuron Signs

Neuronopathy, Distal Hereditary Motor, With Pyramidal Features

Als 4

Distal Hereditary Motor Neuropathy With Pyramidal Features

Amyotrophic Lateral Sclerosis Juvenile 4

Neuronopathy Distal Hereditary Motor With Pyramidal Features

Sclerosis, Lateral, Amyotrophic, Type Type 4

Motor Neuron Disease

Anterior Horn Cell Disease

Motor Neuron Diseases

Mnd - [Motor Neurone Disease]

Lou Gehrig Disease

Creeping Palsy

Creeping Paralysis

Bulbar Motor Neuron Disease

Bulbar Syndrome

Anterior Horn Cell Disorder

Hereditary Motor Neuron Disease

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy

Steele-Richardson-Olszewski Syndrome

Supranuclear Palsy, Progressive

Progressive Supranuclear Ophthalmoplegia

Psp

PSNP1

Familial Progressive Supranuclear Palsy

Richardson'S Syndrome

Psp Syndrome

Progressive Supranuclear Palsy 1

Supranuclear Palsy Progressive

Ophthalmoplegia, Supranuclear, Progressive

Steele-Richardson-Olszewksi Syndrome

Pick Disease Of Brain

Pick Disease

Pick'S Disease

Pick Disease Of The Brain

Lobar Atrophy Of Brain

Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions

Behavioral Variant Of Frontotemporal Dementia

Dementia In Pick'S Disease

Lobar Atrophy Of The Brain

Bvftd

Bv-Ftd

PIDB

Picks Disease

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia

Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus UBQLN2 VGNC VGNC:66782
Rattus norvegicus UBQLN2 RGD RGD:1563566
Mus musculus UBQLN2 MGD MGI:1860283
Bos taurus UBQLN2 VGNC VGNC:36614
Canis familiaris UBQLN2 VGNC VGNC:48085