GALNT13 - polypeptide N-acetylgalactosaminyltransferase 13 Gene

Homo sapiens

Also known as GalNAc-T13

Gene ID: 114805 | Gene type: protein coding

About GALNT13

Cytogenetic location: 2q23.3-q24.1 Genomic coordinates (GRCh38): 2:153,732,769-154,454,177 (from NCBI)

This gene has 10 transcripts (splice variants), 242 orthologues and 19 paralogues. Biased expression in brain (RPKM 11.3), adrenal (RPKM 2.3) and 5 other tissues.

Summary

The GALNT13 protein is a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAcT; EC 2.4.1.41) family, which initiate O-linked glycosylation of mucins (see MUC3A, MIM 158371) by the initial transfer of N-acetylgalactosamine (GalNAc) with an alpha-linkage to a serine or threonine residue.[supplied by OMIM, Apr 2004]

GALNT13 Products(11)

mRNA	Protein	Name
NM_001301627.2	NP_001288556.1	polypeptide N-acetylgalactosaminyltransferase 13 isoform 2
NM_001376392.1	NP_001363321.1	polypeptide N-acetylgalactosaminyltransferase 13 isoform 1
NM_001376394.1	NP_001363323.1	polypeptide N-acetylgalactosaminyltransferase 13 isoform 1
NM_001376398.1	NP_001363327.1	polypeptide N-acetylgalactosaminyltransferase 13 isoform 1
NM_001376400.1	NP_001363329.1	polypeptide N-acetylgalactosaminyltransferase 13 isoform 1
NM_001376401.1	NP_001363330.1	polypeptide N-acetylgalactosaminyltransferase 13 isoform 1
NM_001376402.1	NP_001363331.1	polypeptide N-acetylgalactosaminyltransferase 13 isoform 1
NM_001376403.1	NP_001363332.1	polypeptide N-acetylgalactosaminyltransferase 13 isoform 3
NM_001376404.1	NP_001363333.1	polypeptide N-acetylgalactosaminyltransferase 13 isoform 3
NM_001376405.1	NP_001363334.1	polypeptide N-acetylgalactosaminyltransferase 13 isoform 4
NM_052917.4	NP_443149.2	polypeptide N-acetylgalactosaminyltransferase 13 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables polypeptide N-acetylgalactosaminyltransferase activity	IDA IDA: Inferred from direct assay	22186971	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein O-linked glycosylation via serine	IDA IDA: Inferred from direct assay	22186971	GOA
involved in protein O-linked glycosylation via threonine	IDA IDA: Inferred from direct assay	22186971	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALNT13 Protein Structure

Glycos_transf_2

Ricin_B_lectin

0
100
200
300
400
500
556 a.a.

Protein Preferred Names

Protein Names

polypeptide N-acetylgalactosaminyltransferase 13

GalNAc transferase 13

Related Diseases

Diseases

Alias

Sphenoorbital Meningioma

Tricuspid Valve Insufficiency

Tricuspid Regurgitation	Tricuspid Valve Regurgitation
Tricuspid Incompetence	Tr - [Tricuspid Regurgitation]
Tricuspid Valve Incompetency	Tricuspid Valve Annular Incompetency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70294	N-Acetylgalactosaminyltransferase 13		/	Unkown
HY-RS05251	GALNT13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GALNT13	RGD	RGD:735044
Canis familiaris	GALNT13	VGNC	VGNC:41088
Mus musculus	GALNT13	MGD	MGI:2139447
Bos taurus	GALNT13	VGNC	VGNC:29226
Macaca mulatta	GALNT13	VGNC	VGNC:104531
Felis catus	GALNT13	VGNC	VGNC:62445

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