OSBPL7 - oxysterol binding protein like 7 Gene

Homo sapiens

Also known as ORP7

Gene ID: 114881 | Gene type: protein coding

About OSBPL7

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,807,372-47,821,794 (from NCBI)

This gene has 11 transcripts (splice variants), 274 orthologues and 11 paralogues. Broad expression in stomach (RPKM 18.4), duodenum (RPKM 12.5) and 22 other tissues.

Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

OSBPL7 Products(1)

mRNA	Protein	Name
NM_145798.3	NP_665741.1	oxysterol-binding protein-related protein 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cholesterol binding	IDA IDA: Inferred from direct assay	17428193	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21669198	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cholesterol	IMP IMP: Inferred from mutant phenotype	21669198	GOA
involved in positive regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	21669198	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in autophagosome	IDA IDA: Inferred from direct assay	21669198	GOA
located in cytosol	IDA IDA: Inferred from direct assay	14593528	GOA
located in perinuclear endoplasmic reticulum	IDA IDA: Inferred from direct assay	14593528	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	14593528	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSBPL7 Protein Structure

PH_8

Oxysterol_BP

0
200
400
600
842 a.a.

Protein Preferred Names

Protein Names

oxysterol-binding protein-related protein 7

ORP-7

Related Diseases

Diseases

Alias

Opisthorchiasis

Infection By Opisthorchis	Infection Due To Opisthorchis
Infection Due To Cat Liver Fluke	Infection By Cat Liver Fluke
Opisthorchiosis	Cat Liver Fluke Fever
Cat Liver Fluke Disease	Opisthorchis Infestation
Cat Liver Fluke Infestation

Adult Medulloblastoma

Adult Brain Medulloblastoma

Medulloblastoma, Adult

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-143200	OSBPL7-IN-1		99.79%	Unkown
HY-RS09844	OSBPL7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OSBPL7	VGNC	VGNC:75626
Rattus norvegicus	OSBPL7	RGD	RGD:1309141
Bos taurus	OSBPL7	VGNC	VGNC:32465
Felis catus	OSBPL7	VGNC	VGNC:63982
Mus musculus	OSBPL7	MGD	MGI:1918490
Canis familiaris	OSBPL7	VGNC	VGNC:44157

Name
Email *

	Sorry, but the email address you supplied was invalid.