CIDEA - cell death inducing DFFA like effector a Gene

Homo sapiens

Also known as CIDE-A

Gene ID: 1149 | Gene type: protein coding

About CIDEA

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:12,254,361-12,277,595 (from NCBI)

This gene has 4 transcripts (splice variants), 175 orthologues and 3 paralogues. Restricted expression toward fat (RPKM 78.2).

Summary

This gene encodes the homolog of the mouse protein Cidea that has been shown to activate Apoptosis. This activation of Apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by Caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]

CIDEA Products(2)

mRNA	Protein	Name
NM_001279.4	NP_001270.1	cell death activator CIDE-A isoform 1
NM_001318383.2	NP_001305312.1	cell death activator CIDE-A isoform 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in lipid droplet fusion	IDA IDA: Inferred from direct assay	19843876	GOA
involved in lipid storage	IDA IDA: Inferred from direct assay	19843876	GOA
involved in negative regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	15919794	GOA
involved in negative regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	26118629	GOA
involved in negative regulation of lipid catabolic process	IMP IMP: Inferred from mutant phenotype	15919794	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	15919794	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with lipid droplet	IDA IDA: Inferred from direct assay	18509062	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIDEA Protein Structure

CIDE-N

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

cell death activator CIDE-A

Related Diseases

Diseases

Alias

Lipomatosis, Multiple Symmetric

Multiple Symmetric Lipomatosis	Lipomatosis, Familial Benign Cervical
Lipomatosis, Multiple Symmetrical	Lipodystrophy, Cephalothoracic
Benign Symmetrical Lipomatosis	Madelung Disease
Madelung'S Disease	MSL
Cervical Symmetrical Lipomatosis	Launois-Bensaude'S Lipomatosis
Madelung'S Neck	Multiple Symmetrical Lipomatosis
Familial Symmetric Lipomatosis	Launois-Bensaude Syndrome
Cephalothoracic Lipodystrophy	Familial Benign Cervical Lipomatosis
Launois-Bensaude Lipomatosis

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y0598	trans-Chalcone		98.65%	Unkown
HY-RS02711	CIDEA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CIDEA	VGNC	VGNC:39271
Macaca mulatta	CIDEA	VGNC	VGNC:104219
Rattus norvegicus	CIDEA	RGD	RGD:1305106
Bos taurus	CIDEA	VGNC	VGNC:106691
Mus musculus	CIDEA	MGD	MGI:1270845

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