SLC26A9 - solute carrier family 26 member 9 Gene

Homo sapiens

Gene ID: 115019 | Gene type: protein coding

About SLC26A9

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,913,052-205,943,456 (from NCBI)

This gene has 6 transcripts (splice variants), 187 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in salivary gland (RPKM 19.0), stomach (RPKM 12.3) and 5 other tissues.

Summary

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.[provided by RefSeq, Dec 2008]

SLC26A9 Products(2)

mRNA	Protein	Name
NM_052934.4	NP_443166.1	solute carrier family 26 member 9 isoform a
NM_134325.3	NP_599152.2	solute carrier family 26 member 9 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	19289574	GOA
enables chloride channel activity	IDA IDA: Inferred from direct assay	17673510	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28360110	GOA
enables solute:inorganic anion antiporter activity	IDA IDA: Inferred from direct assay	15800055	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chloride transmembrane transport	IDA IDA: Inferred from direct assay	15800055	GOA
involved in chloride transport	IDA IDA: Inferred from direct assay	17673510	GOA
involved in monoatomic anion transport	IDA IDA: Inferred from direct assay	17673510	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	20658517	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Golgi membrane	IDA IDA: Inferred from direct assay	26801567	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	20658517	GOA
located in cell surface	IDA IDA: Inferred from direct assay	17673510	GOA
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	26801567	GOA
is active in endosome membrane	IDA IDA: Inferred from direct assay	26801567	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	26801567	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC26A9 Protein Structure

Sulfate_transp

STAS

0
200
400
600
791 a.a.

Protein Preferred Names

Protein Names

solute carrier family 26 member 9

anion transporter/exchanger protein 9

Related Diseases

Diseases

Alias

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Ileus

Ileus Of Intestine

Parotid Gland Cancer

Cancer Of Parotid Gland	Parotid Neoplasms
Malignant Neoplasm Of The Parotid	Malignant Tumor Of Parotid Gland
Parotid Cancer	Parotid Neoplasm
Parotid Gland Carcinoma	Cancer Of Parotid
Malignant Tumour Of Parotid Gland	Parotid Duct Cancer
Parotid Ductal Cancer	Parotid Glandular Cancer
Primary Malignant Neoplasm Of Parotid Gland

Pendred Syndrome

Goiter-Deafness Syndrome	Deafness With Goiter
PDS	Thyroid Dyshormonogenesis 2b
Tdh2b	Autosomal Recessive Sensorineural Hearing Impairment And Goiter
Pendred'S Syndrome	Thyroid Hormonogenesis, Genetic Defect In, 2b
Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b	Congenital Hypothyroidism Due To Dyshormonogenesis 2b
Genetic Defect In Thyroid Hormonogenesis 2b	Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter
Goiter-Hearing Loss Syndrome	Goitre-Deafness Syndrome
Goitre Deafness

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159706	S9-A13	Inhibitor	/	Unkown
HY-RS13143	SLC26A9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC26A9	MGD	MGI:2444594
Bos taurus	SLC26A9	VGNC	VGNC:34784
Macaca mulatta	SLC26A9	VGNC	VGNC:77480
Felis catus	SLC26A9	VGNC	VGNC:65287
Canis familiaris	SLC26A9	VGNC	VGNC:46328
Rattus norvegicus	SLC26A9	RGD	RGD:1310441
Others	SLC26A9	NCBI

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