Adam9 - a disintegrin and metallopeptidase domain 9 (meltrin gamma) Gene

Mus musculus

Also known as MDC9; Mltng; mKIAA0021

Gene ID: 11502 | Gene type: protein coding

About Adam9

Summary

Enables SH3 domain binding activity; metalloendopeptidase activity; and protein kinase C binding activity. Involved in several processes, including cell adhesion mediated by integrin; membrane protein ectodomain proteolysis; and positive regulation of membrane protein ectodomain proteolysis. Located in several cellular components, including cell surface; extracellular space; and plasma membrane. Is intrinsic component of external side of plasma membrane. Is expressed in foregut-midgut junction. Used to study cone-rod dystrophy 9. Human ortholog(s) of this gene implicated in cone-rod dystrophy 9. Orthologous to human ADAM9 (ADAM metallopeptidase domain 9). [provided by Alliance of Genome Resources, Apr 2022]

Adam9 Products(2)

mRNA	Protein	Name
NM_001270996.1	NP_001257925.1	disintegrin and metalloproteinase domain-containing protein 9 isoform 1 precursor
NM_007404.2	NP_031430.2	disintegrin and metalloproteinase domain-containing protein 9 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IDA IDA: Inferred from direct assay	8647900	MGI
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	22480688	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10531379	MGI
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	9857183	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	10825303	MGI
involved in cell migration	IDA IDA: Inferred from direct assay	10825303	MGI
involved in membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	19273593	MGI
involved in positive regulation of membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	9857183	MGI
involved in response to glucocorticoid	IMP IMP: Inferred from mutant phenotype	16311053	MGI
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11955914	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	8647900	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15739225	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	9920899	MGI
located in extracellular space	IMP IMP: Inferred from mutant phenotype	9920899	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15739225	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 9

a disintegrin and metalloproteinase domain 9 (meltrin gamma)	metalloprotease/disintegrin/cysteine-rich protein 9
myeloma cell metalloproteinase

Recombinant Adam9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75531	ADAM9 Protein, Mouse (HEK293, His)	Q61072 (G30-D697)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990027	Izeltabart		98.03%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3722A	Mca-PLAQAV-Dpa-RSSSR-NH2 TFA		99.21%	Unkown
HY-P3722	Mca-PLAQAV-Dpa-RSSSR-NH2		/	Unkown
HY-RS00289	ADAM9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adam9	NCBI	NCBI:8754

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