ADAM9 - ADAM metallopeptidase domain 9 Gene

Homo sapiens

Also known as MCMP; MDC9; CORD9; Mltng

Gene ID: 8754 | Gene type: protein coding

About ADAM9

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:38,996,973-39,105,261 (from NCBI)

This gene has 28 transcripts (splice variants), 1 gene allele, 211 orthologues, 20 paralogues and is associated with 3 phenotypes. Ubiquitous expression in gall bladder (RPKM 19.8), urinary bladder (RPKM 16.8) and 24 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

ADAM9 Products(1)

mRNA	Protein	Name
NM_003816.3	NP_003807.1	disintegrin and metalloproteinase domain-containing protein 9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	10531379	GOA
enables collagen binding	IMP IMP: Inferred from mutant phenotype	15361064	GOA
enables integrin binding	IDA IDA: Inferred from direct assay	15361064	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	17704059	GOA
enables laminin binding	IMP IMP: Inferred from mutant phenotype	15361064	GOA
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	9920899	GOA
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	22480688	GOA
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IDA IDA: Inferred from direct assay	12054541	GOA
enables metallopeptidase activity	IMP IMP: Inferred from mutant phenotype	12535668	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10527948	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid precursor protein catabolic process	IDA IDA: Inferred from direct assay	12054541	GOA
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	11162558	GOA
involved in cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	17704059	GOA
involved in cell-cell adhesion mediated by integrin	IEP IEP: Inferred from expression pattern	17704059	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	15361064	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	22480688	GOA
involved in keratinocyte differentiation	IEP IEP: Inferred from expression pattern	17704059	GOA
involved in membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	9920899	GOA
acts upstream of or within membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	23437250	GOA
involved in membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	22480688	GOA
acts upstream of or within membrane protein intracellular domain proteolysis	IMP IMP: Inferred from mutant phenotype	23437250	GOA
involved in monocyte activation	IMP IMP: Inferred from mutant phenotype	11831872	GOA
acts upstream of positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	17704059	GOA
involved in positive regulation of cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	11162558	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	23437250	GOA
involved in positive regulation of keratinocyte migration	IMP IMP: Inferred from mutant phenotype	17704059	GOA
involved in positive regulation of macrophage fusion	IMP IMP: Inferred from mutant phenotype	11831872	GOA
involved in positive regulation of protein secretion	IDA IDA: Inferred from direct assay	17704059	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	12054541	GOA
involved in response to calcium ion	IMP IMP: Inferred from mutant phenotype	11162558	GOA
involved in response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	17018608	GOA
involved in response to manganese ion	IMP IMP: Inferred from mutant phenotype	11162558	GOA
involved in response to tumor necrosis factor	IDA IDA: Inferred from direct assay	11831872	GOA
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11955914	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12054541	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM9 Protein Structure

Pep_M12B_propep

Reprolysin

Disintegrin

ADAM_CR

0
200
400
600
819 a.a.

Protein Preferred Names

Protein Names

disintegrin and metalloproteinase domain-containing protein 9

ADAM metallopeptidase domain 9 (meltrin gamma)

Recombinant ADAM9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77867	ADAM9 Protein, Human (HEK293, His)	Q13443 (A29-D697)	≥95%

Related Diseases

Diseases

Alias

Cone-Rod Dystrophy 9

CORD9	Dystrophy, Cone-Rod, Type 9
Retinitis Pigmentosa 9

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Retinal Degeneration

Degeneration Of Retina

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990027	Izeltabart		98.03%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3722A	Mca-PLAQAV-Dpa-RSSSR-NH2 TFA		99.21%	Unkown
HY-P3722	Mca-PLAQAV-Dpa-RSSSR-NH2		/	Unkown
HY-RS00289	ADAM9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ADAM9	VGNC	VGNC:59585
Mus musculus	ADAM9	MGD	MGI:105376
Bos taurus	ADAM9	VGNC	VGNC:25613
Macaca mulatta	ADAM9	VGNC	VGNC:82097
Rattus norvegicus	ADAM9	RGD	RGD:621473
Canis familiaris	ADAM9	VGNC	VGNC:37588
Others	ADAM9	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.