ATG4A - autophagy related 4A cysteine peptidase Gene

Homo sapiens

Also known as APG4A; AUTL2; HsAPG4A

Gene ID: 115201 | Gene type: protein coding

About ATG4A

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:108,088,829-108,154,671 (from NCBI)

This gene has 8 transcripts (splice variants), 162 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 5.4), colon (RPKM 5.0) and 25 other tissues.

Summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of Autophagy have been described in some malignant tumors, and a role for Autophagy in controlling the unregulated cell growth linked to Cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. [provided by RefSeq, Mar 2016]

ATG4A Products(7)

mRNA	Protein	Name
NM_001321287.2	NP_001308216.1	cysteine protease ATG4A isoform c
NM_001321288.2	NP_001308217.1	cysteine protease ATG4A isoform c
NM_001321289.2	NP_001308218.1	cysteine protease ATG4A isoform d
NM_001321290.2	NP_001308219.1	cysteine protease ATG4A isoform e
NM_052936.5	NP_443168.2	cysteine protease ATG4A isoform a
NM_178270.4	NP_840054.1	cysteine protease ATG4A isoform b
NM_178271.3	NP_840055.1	cysteine protease ATG4A isoform c

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type peptidase activity	IDA IDA: Inferred from direct assay	12473658	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein-phosphatidylethanolamide deconjugating activity	IDA IDA: Inferred from direct assay	31315929	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	21177865	GOA
involved in autophagy	IDA IDA: Inferred from direct assay	30661429	GOA
involved in protein delipidation	IDA IDA: Inferred from direct assay	29458288	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	12473658	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG4A Protein Structure

Peptidase_C54

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

cysteine protease ATG4A

APG4 autophagy 4 homolog A

ATG4A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATG4A	Q8WYN0	CDKL3	Homo sapiens	Q8IVW4	Y2H Prey Pooling	25416956
Intra	ATG4A	Q8WYN0	CDKL3	Homo sapiens	Q8IVW4	Validated Y2H	25416956
Intra	ATG4A	Q8WYN0	GABARAPL1	Homo sapiens	Q9H0R8	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATG4A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7618	ATG4A Protein, Human (His)	Q8WYN0-1 (M1-V398)	≥95%

ATG4A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80557	ATG4A Antibody	WB, IHC-P, IP	Human

Related Diseases

Diseases

Alias

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01148	ATG4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ATG4A	RGD	RGD:1596915
Bos taurus	ATG4A	VGNC	VGNC:26257
Canis familiaris	ATG4A	VGNC	VGNC:38223
Macaca mulatta	ATG4A	VGNC	VGNC:70082
Mus musculus	ATG4A	MGD	MGI:2147903
Felis catus	ATG4A	VGNC	VGNC:60002
Others	ATG4A	NCBI

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