CDKL3 - cyclin dependent kinase like 3 Gene

Homo sapiens

Also known as NKIAMRE

Gene ID: 51265 | Gene type: protein coding

About CDKL3

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,283,345-134,371,624 (from NCBI)

This gene has 10 transcripts (splice variants), 116 orthologues and 26 paralogues. Biased expression in testis (RPKM 4.9), brain (RPKM 1.0) and 12 other tissues.

Summary

The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CDKL3 Products(7)

mRNA	Protein	Name
NM_001113575.2	NP_001107047.1	cyclin-dependent kinase-like 3 isoform 1
NM_001300853.2	NP_001287782.1	cyclin-dependent kinase-like 3 isoform 3
NM_001349363.2	NP_001336292.1	cyclin-dependent kinase-like 3 isoform 4
NM_001349364.2	NP_001336293.1	cyclin-dependent kinase-like 3 isoform 5
NM_001349365.2	NP_001336294.1	cyclin-dependent kinase-like 3 isoform 5
NM_001349366.2	NP_001336295.1	cyclin-dependent kinase-like 3 isoform 5
NM_016508.4	NP_057592.2	cyclin-dependent kinase-like 3 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDKL3 Protein Structure

Pkinase

0
100
200
300
400
500
592 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase-like 3

serine-threonine protein kinase NKIAMRE

CDKL3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDKL3	Q8IVW4	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	CDKL3	Q8IVW4	ZBTB14	Homo sapiens	O43829	Y2H Prey Pooling	25416956
Intra	CDKL3	Q8IVW4	ZBTB14	Homo sapiens	O43829	Y2H Array	25416956
Intra	CDKL3	Q8IVW4	PIH1D2	Homo sapiens	Q8WWB5	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	PIH1D2	Homo sapiens	Q8WWB5	Validated Y2H	32296183
Intra	CDKL3	Q8IVW4	PIH1D2	Homo sapiens	Q8WWB5	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	DNAAF6	Homo sapiens	Q9NQM4	Y2H Prey Pooling	25416956
Intra	CDKL3	Q8IVW4	DNAAF6	Homo sapiens	Q9NQM4	Y2H Array	25416956
Intra	CDKL3	Q8IVW4	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	31515488
Intra	CDKL3	Q8IVW4	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	CDKL3	Q8IVW4	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	LRP2BP	Homo sapiens	Q9P2M1	Validated Y2H	32296183
Intra	CDKL3	Q8IVW4	LRP2BP	Homo sapiens	Q9P2M1	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	LRP2BP	Homo sapiens	Q9P2M1	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	ATG4A	Homo sapiens	Q8WYN0	Y2H Array	25416956
Intra	CDKL3	Q8IVW4	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	28514442
Intra	CDKL3	Q8IVW4	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	33961781
Intra	CDKL3	Q8IVW4	RABEP1	Homo sapiens	Q15276	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	RABEP1	Homo sapiens	Q15276	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	CDKL3	Q8IVW4	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	CDKL3	Q8IVW4	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	CDKL3	Q8IVW4	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	MDFI	Homo sapiens	Q99750	Y2H Array	25416956
Intra	CDKL3	Q8IVW4	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	CDKL3	Q8IVW4	FXR2	Homo sapiens	P51116	Y2H Array	31515488
Intra	CDKL3	Q8IVW4	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	25416956
Intra	CDKL3	Q8IVW4	FXR2	Homo sapiens	P51116	Validated Y2H	25416956
Intra	CDKL3	Q8IVW4	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	FXR2	Homo sapiens	P51116	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	ZBTB43	Homo sapiens	O43298	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	ZBTB43	Homo sapiens	O43298	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	CDKL3	Q8IVW4	TRIM37	Homo sapiens	O94972	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	TRIM37	Homo sapiens	O94972	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
Intra	CDKL3	Q8IVW4	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	25416956
Intra	CDKL3	Q8IVW4	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	25416956
Intra	CDKL3	Q8IVW4	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
Intra	CDKL3	Q8IVW4	KASH5	Homo sapiens	Q8N6L0	Y2H Array	25416956
Intra	CDKL3	Q8IVW4	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	CDKL3	Q8IVW4	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	CDKL3	Q8IVW4	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Meckel Syndrome, Type 4

Meckel Syndrome 4	MKS4
Meckel-Gruber Syndrome, Type 4	Meckel Syndrome Type 4

Orofaciodigital Syndrome Vi

OFD6	Varadi-Papp Syndrome
Varadi Syndrome	Joubert Syndrome With Orofaciodigital Defect
Orofaciodigital Syndrome Type 6	Orofaciodigital Syndrome 6
Oral-Facial-Digital Syndrome, Type Vi	Ofds Vi
Polydactyly, Cleft Lip/Palate Or Lingual Lump, And Psychomotor Retardation	Polydactyly Cleft Lip Palate Psychomotor Retardation
Oral-Facial-Digital Syndrome Type 6	Polydactyly-Cleft Lip/Palate-Psychomotor Retardation Syndrome
Polydactyly - Cleft Lip/Palate - Psychomotor Retardation	Váradi Syndrome
Váradi-Papp Syndrome	Joubert Syndrome With Oral-Facial-Digital Syndrome
Oral-Facial-Digital Syndrome 6	Joubert-Orofaciodigital Syndrome
Orofaciodigital Syndrome, Type Vi

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161847	HZ1	Inhibitor	99.20%	Unkown
HY-RS02407	CDKL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDKL3	RGD	RGD:619874
Macaca mulatta	CDKL3	VGNC	VGNC:70953
Bos taurus	CDKL3	VGNC	VGNC:27140
Felis catus	CDKL3	VGNC	VGNC:60710
Mus musculus	CDKL3	MGD	MGI:2388268

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