Adora1 - adenosine A1 receptor Gene

Mus musculus

Also known as Ri; A1R; A1AR; AA1R; ARA1; A1-AR

Gene ID: 11539 | Gene type: protein coding

About Adora1

Chromosome 1: 134,126,961-134,163,169 reverse strand.GRCm39:CM000994.3

This gene has 4 transcripts (splice variants), 274 orthologues, 3 paralogues and is associated with 20 phenotypes. Biased expression in adrenal adult (RPKM 63.), cerebellum adult (RPKM 3.8) and 13 other tissues.

Summary

Predicted to enable several functions, including G protein-coupled Adenosine Receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Involved in regulation of sensory perception of pain. Acts upstream of or within several processes, including excitatory postsynaptic potential; negative regulation of long-term synaptic depression; and negative regulation of mucus secretion. Located in dendritic spine. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and heart. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora1 Products(5)

mRNA	Protein	Name
NM_001291928.1	NP_001278857.1	adenosine receptor A1 isoform b
NM_001282945.1	NP_001269874.1	adenosine receptor A1 isoform a
NM_001291930.1	NP_001278859.1	adenosine receptor A1 isoform c
NM_001039510.2	NP_001034599.1	adenosine receptor A1 isoform a
NM_001008533.3	NP_001008533.1	adenosine receptor A1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24259587	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	17428973	MGI
acts upstream of leukocyte migration	IGI IGI: Inferred from genetic interaction	15630442	MGI
acts upstream of long-term synaptic depression	IGI IGI: Inferred from genetic interaction	24259587	MGI
acts upstream of long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	24259587	MGI
acts upstream of mucus secretion	IGI IGI: Inferred from genetic interaction	15630442	MGI
acts upstream of or within negative regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	15630442	MGI
acts upstream of or within negative regulation of leukocyte migration	IGI IGI: Inferred from genetic interaction	15630442	MGI
acts upstream of or within negative regulation of long-term synaptic depression	IGI IGI: Inferred from genetic interaction	24259587	MGI
acts upstream of or within negative regulation of long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	24259587	MGI
acts upstream of or within negative regulation of mucus secretion	IGI IGI: Inferred from genetic interaction	15630442	MGI
acts upstream of or within regulation of glomerular filtration	IMP IMP: Inferred from mutant phenotype	15283758	MGI
involved in regulation of sensory perception of pain	IMP IMP: Inferred from mutant phenotype	18940592	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	24259587	MGI
located in synapse	IDA IDA: Inferred from direct assay	24259587	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adora1 Protein Structure

7tmA_Adenosine_R_A1

0
100
200
300
326 a.a.

Protein Preferred Names

Protein Names

adenosine receptor A1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00391	ADORA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00392	Adora1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00393	Adora1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adora1	NCBI	NCBI:134

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