RASGRP4 - RAS guanyl releasing protein 4 Gene

Homo sapiens

Gene ID: 115727 | Gene type: protein coding

About RASGRP4

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,409,058-38,426,219 (from NCBI)

This gene has 20 transcripts (splice variants), 182 orthologues and 24 paralogues. Biased expression in bone marrow (RPKM 11.0), appendix (RPKM 5.5) and 13 other tissues.

Summary

The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated Ras protein, and the Ras activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

RASGRP4 Products(7)

mRNA	Protein	Name
NM_001146202.2	NP_001139674.1	RAS guanyl-releasing protein 4 isoform b
NM_001146203.2	NP_001139675.1	RAS guanyl-releasing protein 4 isoform c
NM_001146204.2	NP_001139676.1	RAS guanyl-releasing protein 4 isoform d
NM_001146205.2	NP_001139677.1	RAS guanyl-releasing protein 4 isoform e
NM_001146206.2	NP_001139678.1	RAS guanyl-releasing protein 4 isoform f
NM_001146207.2	NP_001139679.1	RAS guanyl-releasing protein 4 isoform g
NM_170604.3	NP_733749.1	RAS guanyl-releasing protein 4 isoform a

RASGRP4 Protein Structure

RasGEF

C1_1

0
200
400
600
673 a.a.

Protein Preferred Names

Protein Names

RAS guanyl-releasing protein 4

guanyl nucleotide releasing protein 4

Related Diseases

Diseases

Alias

Mast-Cell Leukemia

Mast Cell Leukemia	Leukemia, Mast-Cell
Leukemia Mast Cell	Mast Cell Leukaemia Nos
Mast Cell Leukaemia Without Mention Of Remission

Mastocytosis

Mast Cell Disease	Mast Cell Hyperplasia
Urticaria Pigmentosa	Malignant Mastocytoma
Malignant Mast Cell Tumours	Malignant Mastocytosis

Deafness, Autosomal Recessive 97

DFNB97	Autosomal Recessive Nonsyndromic Deafness 97
Autosomal Recessive Deafness 97	Deafness, Autosomal Recessive, 97
Deafness, Autosomal Recessive, Type 97

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Drug-Induced Lupus Erythematosus

Dile	Dil
Drug-Induced Systemic Lupus Erythematosus

Congenital Disorder Of Glycosylation, Type Iii

CDG2I	Congenital Disorder Of Glycosylation Type Iii
Cdgiii	Carbohydrate Deficient Glycoprotein Syndrome Type Iii
Congenital Disorder Of Glycosylation Type 2i	Cog5-Cdg
Cdgiidi	Congenital Disorder Of Glycosylation 2i
Glycosylation, Congenital Disorder Of, Type Iii	Congenital Disorder Of Glycosylation, Type I-Iix

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11696	RASGRP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RASGRP4	VGNC	VGNC:64503
Mus musculus	RASGRP4	MGD	MGI:2386851
Macaca mulatta	RASGRP4	VGNC	VGNC:76509
Bos taurus	RASGRP4	VGNC	VGNC:33750
Rattus norvegicus	RASGRP4	RGD	RGD:620476

Name
Email *

	Sorry, but the email address you supplied was invalid.