CTHRC1 - collagen triple helix repeat containing 1 Gene

Homo sapiens

Gene ID: 115908 | Gene type: protein coding

About CTHRC1

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:103,371,538-103,382,989 (from NCBI)

This gene has 4 transcripts (splice variants), 231 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in gall bladder (RPKM 34.5), urinary bladder (RPKM 33.4) and 12 other tissues.

Summary

This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

CTHRC1 Products(2)

mRNA	Protein	Name
NM_001256099.2	NP_001243028.1	collagen triple helix repeat-containing protein 1 isoform 2
NM_138455.4	NP_612464.1	collagen triple helix repeat-containing protein 1 isoform 1 precursor

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18467647	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTHRC1 Protein Structure

Collagen

0
100
200
243 a.a.

Protein Preferred Names

Protein Names

collagen triple helix repeat-containing protein 1

Recombinant CTHRC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70092	CTHRC1 Protein, Human (HEK293, His)	Q96CG8-1 (S31-K243)	≥95%

Related Diseases

Diseases

Alias

Barrett Esophagus

Barrett'S Esophagus	Barrett Esophagus/Esophageal Adenocarcinoma
Barrett Metaplasia	Barrett'S Ulcer Of Esophagus
Ulcerative Esophagitis	Barrett'S Esophagus With Esophagitis
Barrett'S Oesophagus	Barretts Syndrome
Barrett Syndrome	BE
Peptic Ulcer Of Esophagus	Adenocarcinoma Of Esophagus

Adenocarcinoma

Adenocarcinomas	Adenoacanthoma Of Unspecified Site
Adenocarcinoid Of Unspecified Site	Adenocarcinoid Tumour Of Unspecified Site
Adenocarcinoma And Carcinoid Combined Of Unspecified Site	Adenocarcinoma Nos

Bronchiectasis 1

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03297	CTHRC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CTHRC1	MGD	MGI:1915838
Rattus norvegicus	CTHRC1	RGD	RGD:628801
Macaca mulatta	CTHRC1	VGNC	VGNC:71436
Felis catus	CTHRC1	VGNC	VGNC:61251
Bos taurus	CTHRC1	VGNC	VGNC:27796
Canis familiaris	CTHRC1	VGNC	VGNC:49728
Others	CTHRC1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.