OSR2 - odd-skipped related transciption factor 2 Gene

Homo sapiens

Gene ID: 116039 | Gene type: protein coding

About OSR2

Cytogenetic location: 8q22.2 Genomic coordinates (GRCh38): 8:98,944,442-98,952,100 (from NCBI)

This gene has 10 transcripts (splice variants), 197 orthologues and 1 paralogue. Biased expression in endometrium (RPKM 68.5), ovary (RPKM 33.5) and 8 other tissues.

Summary

OSR2 is a mammalian homolog of the Drosophila odd-skipped family of transcription factors (Lan et al., 2004 [PubMed 15175245]).[supplied by OMIM, Mar 2008]

OSR2 Products(4)

mRNA	Protein	Name
NM_001142462.3	NP_001135934.1	protein odd-skipped-related 2 isoform a
NM_001286841.2	NP_001273770.1	protein odd-skipped-related 2 isoform c
NM_001394683.1	NP_001381612.1	protein odd-skipped-related 2 isoform d
NM_053001.4	NP_443727.2	protein odd-skipped-related 2 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSR2 Protein Structure

zf-H2C2_2

zf-C2H2

0
100
200
312 a.a.

Protein Preferred Names

Protein Names

protein odd-skipped-related 2

odd-skipped related 2

Related Diseases

Diseases

Alias

Cleft Soft Palate

Cleft Velum	Cleft Velum Palatinum
Soft Cleft Palate	Soft Palate Perforation

Blepharophimosis, Ptosis, And Epicanthus Inversus

Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome	BPES
Blepharophimosis Syndrome	Blepharophimosis, Epicanthus Inversus, And Ptosis, Type 1
Blepharophimosis, Ptosis, Epicanthus Inversus Syndrome	Bpes With Duane Retraction Syndrome
Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome Type 2	Blepharophimosis, Ptosis, And Epicanthus Inversus Syndrome Type 1
Blepharophimosis, Epicanthus Inversus, And Ptosis, Type 2	Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome
Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type 2	Bpes Type 2
Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Without Premature Ovarian Failure	Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Plus
3q23 Microdeletion Syndrome	Bpes Plus
Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Type 1	Bpes Type 1
Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome With Premature Ovarian Failure	Blepharophimosis, Ptosis, Epicanthus Inversus
Autosomal Dominant Bpes Type I	Autosomal Recessive Bpes Type I
Bpes Type I	Bpes Type Ii
Bpes Without Ovarian Failure	Bpes With Ovarian Failure
Blepharophimosis Syndrome Type 1	Blepharophimosis Syndrome Type 2

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Peptic Ulcer Perforation

Perforated Peptic Ulcer	Acute Peptic Ulcer With Perforation
Peptic Ulcer With Perforation

Cleft Palate With Or Without Ankyloglossia, X-Linked

Cleft Palate With Ankyloglossia	CPX
X-Linked Cleft Palate And Ankyloglossia	X-Linked Cleft Palate With Or Without Ankyloglossia
X-Linked Cleft Palate	X-Linked Cleft Palate With Ankyloglossia
Cleft Palate, With/Without Ankyloglossia, X-Linked

Orofacial Cleft

Cleft, Orofacial

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09853	OSR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OSR2	VGNC	VGNC:84097
Rattus norvegicus	OSR2	RGD	RGD:1305812
Canis familiaris	OSR2	VGNC	VGNC:44169
Bos taurus	OSR2	VGNC	VGNC:32477
Felis catus	OSR2	VGNC	VGNC:63990
Mus musculus	OSR2	MGD	MGI:1930813

Name
Email *

	Sorry, but the email address you supplied was invalid.