2. Gene
  3. LRRC3B - leucine rich repeat containing 3B Gene

LRRC3B - leucine rich repeat containing 3B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as LRP15

Gene ID: 116135 | Gene type: protein coding

About LRRC3B

Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38): 3:26,622,772-26,710,776 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues and 22 paralogues. Biased expression in brain (RPKM 1.4), testis (RPKM 0.6) and 3 other tissues.

Summary

The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast Cancer tissues. The promoter of this gene is frequently hypermethylated in these Cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

LRRC3B Products(8)

mRNA Protein Name
NM_001317808.2 NP_001304737.1 leucine-rich repeat-containing protein 3B precursor
NM_001317809.2 NP_001304738.1 leucine-rich repeat-containing protein 3B precursor
NM_001317810.3 NP_001304739.1 leucine-rich repeat-containing protein 3B precursor
NM_001317811.2 NP_001304740.1 leucine-rich repeat-containing protein 3B precursor
NM_001395645.1 NP_001382574.1 leucine-rich repeat-containing protein 3B precursor
NM_001395646.1 NP_001382575.1 leucine-rich repeat-containing protein 3B precursor
NM_001395647.1 NP_001382576.1 leucine-rich repeat-containing protein 3B precursor
NM_052953.4 NP_443185.1 leucine-rich repeat-containing protein 3B precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC3B Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (33 - 63)

LRR_8

LRR_8: Leucine rich repeat (69 - 111)

LRR_1

LRR_1: Leucine Rich Repeat (115 - 136)

  • 0
  • 100
  • 200
  • 259 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat-containing protein 3B

leucine-rich repeat protein 15

LRRC3B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LRRC3B Q96PB8 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
LRRC3B Q96PB8 EMP1 Homo sapiens P54849
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRRC3B Proteins

Cat. No. Product Name Accession Purity
HY-P70894 LRRC3B Protein, Human (HEK293, His) Q96PB8 (C34-Y204) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07817 LRRC3B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LRRC3B VGNC VGNC:52799
Rattus norvegicus LRRC3B RGD RGD:1311897
Mus musculus LRRC3B MGD MGI:2384996
Felis catus LRRC3B VGNC VGNC:63298
Macaca mulatta LRRC3B VGNC VGNC:110356
Canis familiaris LRRC3B VGNC VGNC:52891
Others LRRC3B NCBI