GRIN3B - glutamate ionotropic receptor NMDA type subunit 3B Gene

Homo sapiens

Also known as NR3B; GluN3B

Gene ID: 116444 | Gene type: protein coding

About GRIN3B

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,000,419-1,009,732 (from NCBI)

This gene has 2 transcripts (splice variants), 289 orthologues and 17 paralogues. Ubiquitous expression in spleen (RPKM 1.5), fat (RPKM 1.0) and 21 other tissues.

Summary

The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]

GRIN3B Products(1)

mRNA	Protein	Name
NM_138690.3	NP_619635.1	glutamate receptor ionotropic, NMDA 3B precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	22564863	GOA
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	22564863	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRIN3B Protein Structure

SBP_bac_3

Lig_chan

0
200
400
600
800
1043 a.a.

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, NMDA 3B

N-methyl-D-aspartate receptor subtype 3B

Related Diseases

Diseases

Alias

Depersonalization Disorder

Neurotic Derealization	Depersonalization
Depersonalization/Derealization Disorder	Depersonalisation-Derealization Syndrome
Depersonalisation Disorder	Depersonalisation Neurosis
Depersonalisation Syndrome	Feeling Of Unreality
Feels Own Self Is Unreal	Neurotic State With Depersonalisation
Neurotic State With Depersonalization Episode

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Dissociative Disorder

Dissociative Disorders	Dissociative Disease
Dissociative Reaction

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

West Syndrome

Infantile Spasms	Infantile Spasms Syndrome
Infantile Spasm	X-Linked Infantile Spasm Syndrome
X-Linked Infantile Spasms	Epileptic Encephalopathy, Early Infantile, 1
Is	Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg
West'S Syndrome	Spasms, Infantile
Is -[Infantile Spasm]	Salaam Spasm
Salaam Tic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05807	GRIN3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GRIN3B	RGD	RGD:621705
Felis catus	GRIN3B	VGNC	VGNC:80056
Bos taurus	GRIN3B	VGNC	VGNC:55211
Mus musculus	GRIN3B	MGD	MGI:2150393

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