CLNK - cytokine dependent hematopoietic cell linker Gene

Homo sapiens

Also known as MIST

Gene ID: 116449 | Gene type: protein coding

About CLNK

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:10,486,395-10,734,846 (from NCBI)

This gene has 3 transcripts (splice variants), 122 orthologues and 3 paralogues. Biased expression in kidney (RPKM 1.1), lymph node (RPKM 0.5) and 12 other tissues.

Summary

MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]

CLNK Products(1)

mRNA	Protein	Name
NM_052964.4	NP_443196.2	cytokine-dependent hematopoietic cell linker

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16273093	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	26009488	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLNK Protein Structure

SH2

0
100
200
300
400
428 a.a.

Protein Preferred Names

Protein Names

cytokine-dependent hematopoietic cell linker

mast cell immunoreceptor signal transducer

CLNK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CLNK	Q7Z7G1	EGFR	Homo sapiens	P00533	Protein Array	16273093
Intra	CLNK	Q7Z7G1	ERBB2	Homo sapiens	P04626	Protein Array	16273093

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Leukodystrophy, Hypomyelinating, 6

Habc	Hypomyelinating Leukodystrophy 6
HLD6	H-Abc
Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum	Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum
Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum	HLD
Leukodystrophy, Hypomyelinating, Type 6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02826	CLNK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CLNK	VGNC	VGNC:27454
Macaca mulatta	CLNK	VGNC	VGNC:71196
Rattus norvegicus	CLNK	RGD	RGD:1562417
Felis catus	CLNK	VGNC	VGNC:60969
Mus musculus	CLNK	MGD	MGI:1351468
Canis familiaris	CLNK	VGNC	VGNC:39352

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