2. Gene
  3. Fcgr2a - Fc gamma receptor 2A Gene

Fcgr2a - Fc gamma receptor 2A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Fcgr3; Fcgr3a

Gene ID: 116591 | Gene type: protein coding

About Fcgr2a

Summary

Enables immunoglobulin receptor binding activity. Involved in several processes, including regulation of Fc-gamma Receptor signaling pathway involved in phagocytosis; regulation of antibody-dependent cellular cytotoxicity; and regulation of tumor necrosis factor production. Located in cell surface. Used to study crescentic glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic Cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to human FCGR2A (Fc fragment of IgG receptor IIa). [provided by Alliance of Genome Resources, Apr 2022]

Fcgr2a Products(1)

mRNA Protein Name
NM_053843.3 NP_446295.2 low affinity immunoglobulin gamma Fc region receptor III
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables immunoglobulin receptor binding IDA
IDA: Inferred from direct assay
22184119 RGD
Biological Process GO Annotation Evidence Reference Source
involved in nerve development IEP
IEP: Inferred from expression pattern
1533683 RGD
involved in regulation of Fc receptor mediated stimulatory signaling pathway IMP
IMP: Inferred from mutant phenotype
16482158 RGD
involved in regulation of antibody-dependent cellular cytotoxicity IMP
IMP: Inferred from mutant phenotype
16482158 RGD
involved in regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
16482158 RGD
involved in regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
22184119 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
22184119 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low affinity immunoglobulin gamma Fc region receptor III

Fc fragment of IgG low affinity IIa receptor for (CD32)

Fc fragment of IgG receptor IIa

Fc fragment of IgG, low affinity IIa, receptor (CD32)

Fc gamma receptor IIa

Fc receptor, IgG, low affinity III

fc-gamma RIII

fcRIII

igG Fc receptor III

Recombinant Fcgr2a Proteins

Cat. No. Product Name Accession Purity
HY-P76233 Fc gamma RIIA/CD32a Protein, Rat (HEK293, Fc) A0A8L2Q236/NP_446295 (D32-L216) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990676 VIB-9600 Inhibitor 99.41% Phase 1
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04828 FCGR2A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fcgr2a NCBI NCBI:2212
Macaca fascicularis Fcgr2a NCBI NCBI:102143568
Macaca mulatta Fcgr2a NCBI NCBI:719996