2. Gene
  3. Map3k8 - mitogen-activated protein kinase kinase kinase 8 Gene

Map3k8 - mitogen-activated protein kinase kinase kinase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Tpl2; Tpl-2; D17TPL2

Gene ID: 116596 | Gene type: protein coding

About Map3k8

Primary_assembly 17: 53,383,131-53,403,216 forward strand.mRatBN7.2:CM026990.1

This gene has 2 transcripts (splice variants), 199 orthologues, 36 paralogues and is associated with 23 phenotypes. Biased expression in Spleen (RPKM 18.2), Lung (RPKM 65.) and 8 other tissues.

Summary

Enables MAP kinase kinase kinase activity. Predicted to be involved in MAPK cascade; immune system process; and protein phosphorylation. Predicted to be located in cytosol. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

Map3k8 Products(1)

mRNA Protein Name
NM_053847.2 NP_446299.2 mitogen-activated protein kinase kinase kinase 8
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables MAP kinase kinase kinase activity EXP
EXP: Inferred from Experiment
8631303 RGD
enables MAP kinase kinase kinase activity IDA
IDA: Inferred from direct assay
8631303 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
8510223 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cardiac ventricle development IEP
IEP: Inferred from expression pattern
9779826 RGD
involved in gap junction-mediated intercellular transport IMP
IMP: Inferred from mutant phenotype
24249418 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map3k8 Protein Structure

STKc_MAP3K8

STKc_MAP3K8: cd13995 (132 - 387)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 467 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 8

serine/threonine kinase (Tpl-2)

tumor progression locus 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12358 Tpl2 Kinase Inhibitor 1 Inhibitor 99.22% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map3k8 NCBI NCBI:1326