2. Gene
  3. MAP3K8 - mitogen-activated protein kinase kinase kinase 8 Gene

MAP3K8 - mitogen-activated protein kinase kinase kinase 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as COT; EST; ESTF; TPL2; AURA2; MEKK8; Tpl-2; c-COT

Gene ID: 1326 | Gene type: protein coding

About MAP3K8

Cytogenetic location: 10p11.23 Genomic coordinates (GRCh38): 10:30,434,021-30,461,833 (from NCBI)

This gene has 7 transcripts (splice variants), 199 orthologues, 35 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 18.4), appendix (RPKM 6.8) and 17 other tissues.

Summary

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

MAP3K8 Products(9)

mRNA Protein Name
XM_017015714.2 XP_016871203.1 mitogen-activated protein kinase kinase kinase 8 isoform X2
XM_017015710.1 XP_016871199.1 mitogen-activated protein kinase kinase kinase 8 isoform X1
XM_047424623.1 XP_047280579.1 mitogen-activated protein kinase kinase kinase 8 isoform X1
NM_005204.4 NP_005195.2 mitogen-activated protein kinase kinase kinase 8
XM_047424622.1 XP_047280578.1 mitogen-activated protein kinase kinase kinase 8 isoform X1
NM_001320961.2 NP_001307890.1 mitogen-activated protein kinase kinase kinase 8
XM_017015709.3 XP_016871198.1 mitogen-activated protein kinase kinase kinase 8 isoform X1
XM_047424624.1 XP_047280580.1 mitogen-activated protein kinase kinase kinase 8 isoform X1
NM_001244134.1 NP_001231063.1 mitogen-activated protein kinase kinase kinase 8
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables MAP kinase kinase kinase activity IDA
IDA: Inferred from direct assay
1833717 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12832462 GOA
Biological Process GO Annotation Evidence Reference Source
involved in MAPK cascade IDA
IDA: Inferred from direct assay
1833717 GOA
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
16424369 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
1833717 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K8 Protein Structure

Pkinase

Pkinase: Protein kinase domain (144 - 386)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 467 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 8

Ewing sarcoma transformant

augmented in rheumatoid arthritis 2

cot (cancer Osaka thyroid) oncogene

proto-oncogene c-Cot

proto-oncogene serine/threoine protein kinase

tumor progression locus 2

MAP3K8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MAP3K8 P41279 NFKB1 Homo sapiens P19838
Anti Tag CoIP
25852190
Intra MAP3K8 P41279 NFKB1 Homo sapiens P19838
Anti Tag CoIP
12832462
Intra MAP3K8 P41279 NFKB1 Homo sapiens P19838
Y2H
21988832
Intra MAP3K8 P41279 NFKB1 Homo sapiens P19838
Pull Down
12832462
Intra MAP3K8 P41279 NFKB2 Homo sapiens Q00653
TAP
14743216
Intra MAP3K8 P41279 NFKB2 Homo sapiens Q00653
Anti Tag CoIP
25852190
Intra MAP3K8 P41279 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
22939624
Intra MAP3K8 P41279 TNIP2 Homo sapiens Q8NFZ5
Pull Down
15169888
Intra MAP3K8 P41279 TNIP2 Homo sapiens Q8NFZ5
Anti Bait CoIP
15169888
Intra MAP3K8 P41279 TNIP2 Homo sapiens Q8NFZ5
Anti Tag CoIP
25852190
Intra MAP3K8 P41279 PIN1 Homo sapiens Q13526
Y2H
24265246
Intra MAP3K8 P41279 PIN1 Homo sapiens Q13526
Pull Down
24265246
Intra MAP3K8 P41279 PIN1 Homo sapiens Q13526
Anti Tag CoIP
24265246
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAP3K8 Proteins

Cat. No. Product Name Accession Purity
HY-P75921 MAP3K8/TPL-2 Protein, Human (sf9, GST) P41279 (M30-R397) ≥95%

Related Diseases

Diseases Alias
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

Primitive Neuroectodermal Tumor

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Ewing Family Of Tumors

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Spitzoid Melanoma

Atypical Spitz Nevus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12358 Tpl2 Kinase Inhibitor 1 Inhibitor 99.22% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MAP3K8 VGNC VGNC:97497
Bos taurus MAP3K8 VGNC VGNC:31202
Canis familiaris MAP3K8 VGNC VGNC:42979
Rattus norvegicus MAP3K8 RGD RGD:620969
Mus musculus MAP3K8 MGD MGI:1346878
Macaca mulatta MAP3K8 VGNC VGNC:81464
Others MAP3K8 NCBI