ADCYAP1R1 - ADCYAP receptor type I Gene

Homo sapiens

Also known as PAC1; PAC1R; PACAPR; PACAPRI

Gene ID: 117 | Gene type: protein coding

About ADCYAP1R1

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:31,052,308-31,111,474 (from NCBI)

This gene has 8 transcripts (splice variants), 259 orthologues and 42 paralogues. Biased expression in brain (RPKM 39.8), adrenal (RPKM 5.5) and 1 other tissue.

Summary

This gene encodes type I Adenylate Cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/Secretin Receptor family. This receptor mediates diverse biological actions of Adenylate Cyclase activating polypeptide 1 and is positively coupled to Adenylate Cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]

ADCYAP1R1 Products(4)

mRNA	Protein	Name
NM_001118.5	NP_001109.2	pituitary adenylate cyclase-activating polypeptide type I receptor isoform 3 precursor
NM_001199635.2	NP_001186564.1	pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1 precursor
NM_001199636.2	NP_001186565.1	pituitary adenylate cyclase-activating polypeptide type I receptor isoform 2 precursor
NM_001199637.2	NP_001186566.1	pituitary adenylate cyclase-activating polypeptide type I receptor isoform 4 precursor

ADCYAP1R1 Protein Structure

HRM

7tm_2

0
100
200
300
400
468 a.a.

Protein Preferred Names

Protein Names

pituitary adenylate cyclase-activating polypeptide type I receptor

PACAP receptor 1

Recombinant ADCYAP1R1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77120	ADCYAP1R1 Protein, Human (HEK293, Fc)	P41586 (M1-A155)	≥95%

Related Diseases

Diseases

Alias

Accommodative Spasm

Spasm Of Accommodation	Cyclospasm
Ciliary Muscle Spasm	Ciliary Body Spasm

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Chondrodysplasia, Blomstrand Type

Chondrodysplasia Blomstrand Type	BOCD
Blomstrand Lethal Chondrodysplasia	Blomstrand Lethal Osteochondrodysplasia
Blomstrand'S Lethal Chondrodysplasia	Blc
Blomstrand Chondrodysplasia	Blomstrand Osteochondrodysplasia

Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib	IGHD1B
Ighd Ib	Growth Hormone Deficiency, Isolated, Type Ib
Congenital Ighd Type Ib	Congenital Isolated Gh Deficiency Type Ib
Congenital Isolated Growth Hormone Deficiency Type Ib	Dwarfism Of Sindh
Pituitary Dwarfism I	Isolated Growth Hormone Deficiency Type 1b
Ighd 1b	Growth Hormone Deficiency, Isolated, 1b

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Post-Traumatic Stress Disorder

PTSD	Traumatic Neurosis
Post Traumatic Stress Disorder	Stress Disorders, Post-Traumatic
Posttraumatic Stress Disorder	Ptsd - [Post Traumatic Stress Disorder]
Trauma-Related Disorders

Photokeratitis

Acute Endometritis

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00337	ADCYAP1R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADCYAP1R1	MGD	MGI:108449
Rattus norvegicus	ADCYAP1R1	RGD	RGD:2038
Felis catus	ADCYAP1R1	VGNC	VGNC:59623
Macaca mulatta	ADCYAP1R1	VGNC	VGNC:69526
Bos taurus	ADCYAP1R1	VGNC	VGNC:25652
Canis familiaris	ADCYAP1R1	VGNC	VGNC:37627
Others	ADCYAP1R1	NCBI

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