2. Gene
  3. Birc5 - baculoviral IAP repeat-containing 5 Gene

Birc5 - baculoviral IAP repeat-containing 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Api4; TIAP; AAC-11; survivin40

Gene ID: 11799 | Gene type: protein coding

About Birc5

Summary

This gene is a member of the inhibitor of Apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. In humans, gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts have been identified in human that regulate this gene's expression. At least three transcript variants encoding distinct isoforms have been found for this gene, although at least one of these transcript variants is a nonsense-mediated decay (NMD) candidate. [provided by RefSeq, Jul 2008]

Birc5 Products(2)

mRNA Protein Name
NM_001012273.1 NP_001012273.1 baculoviral IAP repeat-containing protein 5 isoform 3
NM_009689.2 NP_033819.1 baculoviral IAP repeat-containing protein 5 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17881355 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within embryo development IMP
IMP: Inferred from mutant phenotype
11084331 MGI
involved in meiosis I IDA
IDA: Inferred from direct assay
25645018 MGI
acts upstream of or within microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
11084331 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12679106 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
25778398 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
16049172 MGI
acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
19644667 MGI
acts upstream of or within regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
19644667 MGI
acts upstream of or within regulation of type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
19644667 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in chromosome, centromeric region IDA
IDA: Inferred from direct assay
25645018 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12679106 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

baculoviral IAP repeat-containing protein 5

apoptosis inhibitor 4

apoptosis inhibitor survivin

survivin

Recombinant Birc5 Proteins

Cat. No. Product Name Accession Purity
HY-P71717 Apoptosis inhibitor 4/Birc5 Protein, Mouse (P.pastoris, His) O70201 (M1-A140) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01513 BIRC5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Birc5 NCBI NCBI:332