Areg - amphiregulin Gene

Mus musculus

Also known as AR; Mcub; Sdgf

Gene ID: 11839 | Gene type: protein coding

About Areg

Summary

This gene encodes a member of the epidermal growth factor (EGF) family and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to play a role in immunity, inflammation, tissue repair, and lung and mammary gland development. Homozygous knockout mice for this gene exhibit impaired immune system regulation in the skin and gene expression changes characteristic of chronic liver damage. [provided by RefSeq, Aug 2015]

Areg Products(1)

mRNA	Protein	Name
NM_009704.4	NP_033834.1	amphiregulin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables receptor ligand activity	IGI IGI: Inferred from genetic interaction	23086930	MGI
enables transmembrane receptor protein tyrosine kinase activator activity	IGI IGI: Inferred from genetic interaction	23086930	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	17369357	MGI
involved in epidermal growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	23086930	MGI
acts upstream of or within epithelial cell proliferation involved in mammary gland duct elongation	IMP IMP: Inferred from mutant phenotype	17369357	MGI
acts upstream of or within mammary gland alveolus development	IGI IGI: Inferred from genetic interaction	10331984	MGI
acts upstream of or within mammary gland branching involved in thelarche	IMP IMP: Inferred from mutant phenotype	10331984	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	8702723	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8702723	MGI
acts upstream of or within response to estradiol	IDA IDA: Inferred from direct assay	17369357	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8588926	MGI
is active in extracellular space	IDA IDA: Inferred from direct assay	23086930	MGI
is active in extracellular space	IGI IGI: Inferred from genetic interaction	30770250	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	8588926	MGI
located in nucleus	IDA IDA: Inferred from direct assay	8588926	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

amphiregulin

schwannoma-derived growth factor

Recombinant Areg Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77868	Amphiregulin Protein, Mouse (HEK293, Fc)	P31955 (V100-A248)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00892	AREG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Areg	NCBI	NCBI:374

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