MMP21 - matrix metallopeptidase 21 Gene

Homo sapiens

Also known as HTX7; MMP-21

Gene ID: 118856 | Gene type: protein coding

About MMP21

Cytogenetic location: 10q26.2 Genomic coordinates (GRCh38): 10:125,766,453-125,775,821 (from NCBI)

This gene has 4 transcripts (splice variants), 156 orthologues, 23 paralogues and is associated with 4 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]

MMP21 Products(1)

mRNA	Protein	Name
NM_147191.1	NP_671724.1	matrix metalloproteinase-21 preproprotein

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	26429889	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP21 Protein Structure

PG_binding_1

Peptidase_M10

Hemopexin

0
100
200
300
400
500
569 a.a.

Protein Preferred Names

Protein Names

matrix metalloproteinase-21

matrix metalloproteinase 21

Related Diseases

Diseases

Alias

Heterotaxy, Visceral, 7, Autosomal

HTX7	Heterotaxy, Visceral, Autosomal, Type 7

Dextrocardia With Situs Inversus

Situs Inversus Totalis	Complete Situs Inversus
Complete Situs Inversus Viscerum	Situs Inversus

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Borna Disease

Enzootic Encephalomyelitis

Phonagnosia

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08541	MMP21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MMP21	VGNC	VGNC:63537
Mus musculus	MMP21	MGD	MGI:2664387
Macaca mulatta	MMP21	VGNC	VGNC:74754
Canis familiaris	MMP21	VGNC	VGNC:43282
Rattus norvegicus	MMP21	RGD	RGD:1309332

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