COMTD1 - catechol-O-methyltransferase domain containing 1 Gene

Homo sapiens

Gene ID: 118881 | Gene type: protein coding

About COMTD1

This gene has 7 transcripts (splice variants), 257 orthologues and 2 paralogues. Broad expression in colon (RPKM 11.0), stomach (RPKM 8.5) and 24 other tissues.

Summary

Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in methylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

COMTD1 Products(1)

mRNA	Protein	Name
NM_144589.4	NP_653190.2	catechol O-methyltransferase domain-containing protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMTD1 Protein Structure

Methyltransf_3

0
100
200
262 a.a.

Protein Preferred Names

Protein Names

catechol O-methyltransferase domain-containing protein 1

Related Diseases

Diseases

Alias

Tatton-Brown-Rahman Syndrome

TBRS	Dnmt3a Overgrowth Syndrome
Tatton-Brown-Rahman Overgrowth Syndrome	Dos
Dnmt3a-Related Overgrowth Syndrome	Doid:0112339
Dose

Hematuria, Benign Familial

Benign Familial Hematuria	BFH
Thin Membrane Nephropathy	Tmn
Thin Basement Membrane Nephropathy	Thin-Basement-Membrane Nephropathy
Hematuria, Familial Benign	Hematuria Benign Familial
Hematuria, Benign, Familial	Thin Basement Membrane Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03019	COMTD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	COMTD1	MGD	MGI:1916406
Rattus norvegicus	COMTD1	RGD	RGD:1306581
Bos taurus	COMTD1	VGNC	VGNC:27591
Macaca mulatta	COMTD1	VGNC	VGNC:71353
Canis familiaris	COMTD1	VGNC	VGNC:39502
Felis catus	COMTD1	VGNC	VGNC:61080

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