Blm - Bloom syndrome, RecQ like helicase Gene

Mus musculus

Gene ID: 12144 | Gene type: protein coding

About Blm

Summary

Enables 3'-5' DNA helicase activity. Involved in G-quadruplex DNA unwinding and replication fork processing. Acts upstream of or within several processes, including DNA metabolic process; negative regulation of thymocyte apoptotic process; and regulation of DNA recombination. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and mammary gland. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Bloom syndrome. Orthologous to human BLM (BLM RecQ like helicase). [provided by Alliance of Genome Resources, Apr 2022]

Blm Products(2)

mRNA	Protein	Name
NM_001042527.2	NP_001035992.1	recQ-like DNA helicase BLM isoform 2
NM_007550.4	NP_031576.4	recQ-like DNA helicase BLM isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5' DNA helicase activity	IDA IDA: Inferred from direct assay	9840919	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15364958	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DN4 thymocyte differentiation	IMP IMP: Inferred from mutant phenotype	17210642	MGI
acts upstream of or within DNA repair	IDA IDA: Inferred from direct assay	15364958	MGI
involved in DNA replication	IGI IGI: Inferred from genetic interaction	26195664	MGI
involved in DNA replication	IMP IMP: Inferred from mutant phenotype	26195664	MGI
involved in G-quadruplex DNA unwinding	IGI IGI: Inferred from genetic interaction	26195664	MGI
involved in G-quadruplex DNA unwinding	IMP IMP: Inferred from mutant phenotype	26195664	MGI
acts upstream of or within alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	17210642	MGI
acts upstream of alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	17210642	MGI
acts upstream of or within cellular response to xenobiotic stimulus	IGI IGI: Inferred from genetic interaction	25520194	MGI
acts upstream of or within chromosome organization	IMP IMP: Inferred from mutant phenotype	9808625	MGI
acts upstream of immature T cell proliferation in thymus	IMP IMP: Inferred from mutant phenotype	17210642	MGI
acts upstream of mitotic recombination	IMP IMP: Inferred from mutant phenotype	9808625	MGI
involved in negative regulation of mitotic recombination	IGI IGI: Inferred from genetic interaction	27010503	MGI
acts upstream of or within negative regulation of mitotic recombination	IMP IMP: Inferred from mutant phenotype	9808625	MGI
involved in negative regulation of mitotic recombination	IMP IMP: Inferred from mutant phenotype	27010503	MGI
acts upstream of or within negative regulation of thymocyte apoptotic process	IGI IGI: Inferred from genetic interaction	11046052	MGI
acts upstream of or within negative regulation of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	11046052	MGI
acts upstream of or within positive regulation of alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	17210642	MGI
acts upstream of or within positive regulation of double-strand break repair via homologous recombination	IGI IGI: Inferred from genetic interaction	25520194	MGI
acts upstream of or within positive regulation of immature T cell proliferation in thymus	IMP IMP: Inferred from mutant phenotype	17210642	MGI
acts upstream of or within regulation of binding	IDA IDA: Inferred from direct assay	15364958	MGI
involved in replication fork processing	IMP IMP: Inferred from mutant phenotype	29125140	MGI
acts upstream of or within replication-born double-strand break repair via sister chromatid exchange	IMP IMP: Inferred from mutant phenotype	25597246	MGI
acts upstream of or within telomere maintenance	IGI IGI: Inferred from genetic interaction	15367665	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, telomeric region	IMP IMP: Inferred from mutant phenotype	26195664	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17982445	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	17696610	MGI
located in nucleus	IDA IDA: Inferred from direct assay	29125140	MGI
located in pronucleus	IDA IDA: Inferred from direct assay	17982445	MGI
located in replication fork	IDA IDA: Inferred from direct assay	15364958	MGI
located in replication fork	IMP IMP: Inferred from mutant phenotype	26195664	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

recQ-like DNA helicase BLM

Bloom syndrome protein homolog

Bloom syndrome homolog	Bloom syndrome, RecQ helicase-like
bloom syndrome protein homolog	mBLM
recQ helicase homolog

Recombinant Blm Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72105	BLM Protein, Mouse (His-Myc)	O88700 (I684-Q859)	≥95%

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3239	Belantamab mafodotin		99.60%	Unkown

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12342	ML216	Inhibitor	99.89%	Unkown
HY-110185	NSC 617145	Inhibitor	99.18%	Unkown
HY-111756	BLM-IN-1	Inducer	98.09%	Unkown
HY-128712	NCGC00029283	Inhibitor	98.88%	Unkown
HY-156420	ATUX-1215	Activator	99.94%	Unkown
HY-137992	Aucuparin		/	Unkown
HY-151939	BLM-IN-2	Inducer	/	Unkown
HY-RS01520	BLM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Blm	NCBI	NCBI:641

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