Blm - Bloom syndrome, RecQ like helicase Gene

Mus musculus

Gene ID: 12144 | Gene type: protein coding

About Blm

Summary

Enables 3'-5' DNA helicase activity. Involved in G-quadruplex DNA unwinding and replication fork processing. Acts upstream of or within several processes, including DNA metabolic process; negative regulation of thymocyte apoptotic process; and regulation of DNA recombination. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and mammary gland. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Bloom syndrome. Orthologous to human BLM (BLM RecQ like helicase). [provided by Alliance of Genome Resources, Apr 2022]

Blm Products(2)

mRNA	Protein	Name
NM_001042527.2	NP_001035992.1	recQ-like DNA helicase BLM isoform 2
NM_007550.4	NP_031576.4	recQ-like DNA helicase BLM isoform 1

Protein Preferred Names

Protein Names

recQ-like DNA helicase BLM

Bloom syndrome protein homolog

Bloom syndrome homolog	Bloom syndrome, RecQ helicase-like
bloom syndrome protein homolog	mBLM
recQ helicase homolog

Recombinant Blm Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72105	BLM Protein, Mouse (His-Myc)	O88700 (I684-Q859)	≥95%

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3239	Belantamab mafodotin		99.60%	Unkown

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12342	ML216	Inhibitor	99.89%	Unkown
HY-110185	NSC 617145	Inhibitor	99.18%	Unkown
HY-111756	BLM-IN-1	Inducer	98.09%	Unkown
HY-128712	NCGC00029283	Inhibitor	98.88%	Unkown
HY-156420	ATUX-1215		99.94%	Unkown
HY-137992	Aucuparin		/	Unkown
HY-151939	BLM-IN-2	Inducer	/	Unkown
HY-RS01520	BLM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Blm	NCBI	NCBI:641

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