CMA1 - chymase 1 Gene

Homo sapiens

Also known as CYH; MCT1; chymase

Gene ID: 1215 | Gene type: protein coding

About CMA1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,505,353-24,508,265 (from NCBI)

This gene has 2 transcripts (splice variants), 119 orthologues and 6 paralogues. Biased expression in colon (RPKM 6.3), esophagus (RPKM 4.1) and 11 other tissues.

Summary

This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive Peptides. In the heart and blood vessels, this protein, rather than angiotensin converting Enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]

CMA1 Products(2)

mRNA	Protein	Name
NM_001308083.2	NP_001295012.1	chymase isoform 2
NM_001836.5	NP_001827.1	chymase isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	EXP EXP: Inferred from Experiment	9256427	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	1919436	GOA
enables serine-type peptidase activity	EXP EXP: Inferred from Experiment	2266130	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in basement membrane disassembly	IDA IDA: Inferred from direct assay	27068509	GOA
involved in cytokine precursor processing	IDA IDA: Inferred from direct assay	1919436	GOA
involved in extracellular matrix disassembly	IDA IDA: Inferred from direct assay	27068509	GOA
involved in regulation of inflammatory response	IDA IDA: Inferred from direct assay	1919436	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in secretory granule	IDA IDA: Inferred from direct assay	29529050	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CMA1 Protein Structure

Trypsin

0
100
200
247 a.a.

Protein Preferred Names

Protein Names

chymase

alpha-chymase

Recombinant CMA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74252	Chymase/CMA1 Protein, Human (sf9, His)	P23946 (G20-N247)	≥95%

Related Diseases

Diseases

Alias

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Mastocytosis, Cutaneous

Urticaria Pigmentosa	Cutaneous Mastocytosis
Diffuse Cutaneous Mastocytosis	Maculopapular Cutaneous Mastocytosis
Mastocytosis, Diffuse Cutaneous	MASTC
Mastocytosis, Maculopapular Cutaneous	Mastocytosis, Systemic, Somatic
Mastocytoma	Dcm
Diffuse Cutaneous Maculopapulous Mastocytosis	Up/Mpcm
Cm	Mastocytosis, Systemic
MASTSYS	Mast Cell Disease
Mast-Cell Disease	Mast Cell Leukemia
Mastocytosis, Indolent	Mastocytosis With Associated Hematologic Disorder
Mast Cell Neoplasm	Benign Mastocytoma

Mast Cell Neoplasm

Mastocytoma	Mast Cell Proliferative Disease
Mast Cell Tumor	Benign Mastocytoma

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Solitary Mastocytoma Of The Skin

Cutaneous Solitary Mastocytoma	Skin Mastocytoma
Solitary Mastocytoma	Solitary Mastocytoma Of Skin
Mastocytoma, Skin

Thiopental Allergy

Penthiobarbital Allergy

Pentothiobarbital Allergy

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Peritonitis

Retractile Mesenteritis	Sclerosing Mesenteritis
Acute Generalized Peritonitis	Primary Bacterial Peritonitis
Idiopathic Sclerosing Mesenteritis	Mesenteric Panniculitis
Peritoneal Retractile Mesenteritis	Liposclerotic Mesenteritis
Mesenteric Fibromatosis	Mesenteric Lipodystrophy
Mesenteric Lipogranuloma	Fibromatosis, Abdominal
Peritoneum Inflammation	Peritonitis Of Undetermined Cause
Peritonitis Of Unspecified Cause	Pelviperitonitis
Pelvic Peritonitis, Nos	Generalised Peritonitis Nos
Abdominal Peritonitis	Acute Idiopathic Peritonitis
Acute Lesser Sac Peritonitis	Acute Peritoneal Inflammation
Diffuse Peritonitis	Peritoneal Inflammation
Acute Primary Peritonitis	Pneumococcal Peritonitis

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Ceftriaxone Allergy

Rocephin Allergy

Portal Hypertension

Hypertension, Portal	Hypertension Portal
Pht - [Portal Hypertension]	Portal Htn

Indolent Systemic Mastocytosis

Ism

Vernal Conjunctivitis

Conjunctivitis Vernal

Conjunctivitis, Vernal

Cephalosporin Allergy

Vasomotor Rhinitis

Rhinitis, Vasomotor	Rhinitis Vasomotor
Vmr - [Vasomotor Rhinitis]

Coronary Artery Vasospasm

Coronary Vasospasm

Coronary Artery Spasm

Mast-Cell Sarcoma

Mast Cell Sarcoma

Phenytoin Allergy

Dilantin Allergy

Aggressive Systemic Mastocytosis

Asm	Lymphadenopathic Mastocytosis With Eosinophilia

Papillon-Lefevre Syndrome

Papillon-Lefevre Disease	Papillon-Lefèvre Syndrome
PLS	Keratosis Palmoplantaris With Periodontopathia
PALS	Papillon Lefevre Syndrome
Keratosis Palmoplantar-Periodontopathy Syndrome	Papillon-Lefvre Syndrome
Hyperkeratosis Palmoplantaris With Periodontosis	Keratoris Palmoplantaris With Periodontopathia
Keratosis Palmoplantar - Periodontopathy	Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction
Palmoplantar Keratoderma With Periodontosis	Palsy

Acute Anterolateral Myocardial Infarction

Acute Myocardial Infarction Of Anterolateral Wall

Vulvar Syringoma

Chronic Conjunctivitis

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Aortic Aneurysm, Familial Abdominal, 1

Abdominal Aortic Aneurysm	Aortic Aneurysm, Familial Abdominal 1
Aneurysm, Abdominal Aortic	AAA
Aortic Aneurysm, Abdominal	AAA1
Aortic Aneurysm, Familial Abdominal	Aortic Aneurysm Abdominal
Abdominal Aortic Aneurysms	Abdominal Aortic Aneurysm Without Mention Of Perforation Or Rupture
Abdomen Aneurysm	Abdominal Aorta Aneurysm
Aneurysm Of Abdominal Aorta	Aortic Abdomen Aneurysm
Aaa - [Abdominal Aortic Aneurysm]	Abdominal Aneurysm
Abdominal Aorta Aneurysm Rupture	Abdominal Aorta Aneurysm Ruptured
Abdominal Aortic Aneurysm Which Has Ruptured	Ruptured Aaa
Abdomen Aorta Aneurysm Ruptured	Abdomen Aorta Rupture
Abdomen Aortic Aneurysm Rupture	Abdomen Aneurysm Rupture
Abdomen Aortic Aneurysm Ruptured	Abdomen Aortic Rupture
Abdominal Aorta Rupture	Abdominal Aortic Rupture
Rupture Abdomen Aorta Aneurysm	Rupture Abdominal Aortic Aneurysm
Ruptured Abdomen Aneurysm	Ruptured Abdomen Aorta
Ruptured Abdomen Aortic	Ruptured Abdominal Aneurysm
Ruptured Abdominal Aorta	Ruptured Abdominal Aortic
Ruptured Aorta Abdominalis Aneurysm	False Abdomen Aorta Aneurysm Ruptured
False Abdominal Aortic Aneurysm Ruptured	False Abdominal Aorta Aneurysm Ruptured
False Abdomen Aortic Aneurysm Ruptured

Respiratory Failure

Acute Respiratory Failure	Chronic Respiratory Failure
Respiratory Insufficiency	Acute-On-Chronic Respiratory Failure
Respiratory Disease	Acute And Chronic Respiratory Failure
Respiratory Insufficiency/Failure	Chronic Respiratory Disease
Pulmonary Valve Insufficiency	Chronic Disease Of Respiratory System
Respiration Disorders	Respiratory Tract Diseases
Lung Failure Nos	Pulmonary Failure
Arf - [Acute Respiratory Failure]	Acute Respiratory Insufficiency
Acute Pulmonary Insufficiency	Acute Respiration Failure
Chronic Respiration Failure

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02853	CMA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CMA1	MGD	MGI:96941
Felis catus	CMA1	VGNC	VGNC:81012
Canis familiaris	CMA1	VGNC	VGNC:49768
Macaca mulatta	CMA1	VGNC	VGNC:71270
Rattus norvegicus	CMA1	RGD	RGD:2365
Others	CMA1	NCBI

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