2. Gene
  3. Bmpr1a - bone morphogenetic protein receptor, type 1A Gene

Bmpr1a - bone morphogenetic protein receptor, type 1A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ALK3; Bmpr; SKR5; ALK-3; BMPR-1A; BMPR-IA; 1110037I22Rik

Gene ID: 12166 | Gene type: protein coding

About Bmpr1a

Chromosome 14: 34,132,691-34,225,298 reverse strand.GRCm39:CM001007.3

This gene has 4 transcripts (splice variants), 225 orthologues, 11 paralogues and is associated with 13 phenotypes. Broad expression in bladder adult (RPKM 18.4), limb E14.5 (RPKM 14.7) and 22 other tissues.

Summary

Enables BMP binding activity; BMP Receptor activity; and Enzyme activator activity. Involved in several processes, including circulatory system development; fibrous ring of heart morphogenesis; and positive regulation of cell population proliferation. Acts upstream of or within several processes, including animal organ development; limb morphogenesis; and regionalization. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Ebstein anomaly; Wolff-Parkinson-White syndrome; chromosome 10q23 deletion syndrome; juvenile polyposis syndrome; and osteoarthritis. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A). [provided by Alliance of Genome Resources, Apr 2022]

Bmpr1a Products(1)

mRNA Protein Name
NM_009758.4 NP_033888.2 bone morphogenetic protein receptor type-1A precursor

Bmpr1a Protein Structure

Activin_recp

Activin_recp: pfam01064 (58 - 131)

TGF_beta_GS

TGF_beta_GS: pfam08515 (204 - 231)

STKc_BMPR1a

STKc_BMPR1a: cd14220 (237 - 523)

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  • 532 a.a.
Protein Preferred Names Protein Names

bone morphogenetic protein receptor type-1A

BMP type-1A receptor

BMP-2/BMP-4 receptor

activin receptor-like kinase 3

serine/threonine-protein kinase receptor R5

Recombinant Bmpr1a Proteins

Cat. No. Product Name Accession Purity
HY-P7483 BMPR1A/ALK-3 Protein, Mouse (HEK293, His-Fc) P36895 (Q24-R152) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01546 BMPR1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01547 Bmpr1a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01548 Bmpr1a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmpr1a NCBI NCBI:657
Canis familiaris Bmpr1a NCBI NCBI:489077