Bmpr1a - bone morphogenetic protein receptor, type 1A Gene

Mus musculus

Also known as ALK3; Bmpr; SKR5; ALK-3; BMPR-1A; BMPR-IA; 1110037I22Rik

Gene ID: 12166 | Gene type: protein coding

About Bmpr1a

Chromosome 14: 34,132,691-34,225,298 reverse strand.GRCm39:CM001007.3

This gene has 4 transcripts (splice variants), 225 orthologues, 11 paralogues and is associated with 13 phenotypes. Broad expression in bladder adult (RPKM 18.4), limb E14.5 (RPKM 14.7) and 22 other tissues.

Summary

Enables BMP binding activity; BMP Receptor activity; and Enzyme activator activity. Involved in several processes, including circulatory system development; fibrous ring of heart morphogenesis; and positive regulation of cell population proliferation. Acts upstream of or within several processes, including animal organ development; limb morphogenesis; and regionalization. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Ebstein anomaly; Wolff-Parkinson-White syndrome; chromosome 10q23 deletion syndrome; juvenile polyposis syndrome; and osteoarthritis. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A). [provided by Alliance of Genome Resources, Apr 2022]

Bmpr1a Products(1)

mRNA	Protein	Name
NM_009758.4	NP_033888.2	bone morphogenetic protein receptor type-1A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BMP binding	IDA IDA: Inferred from direct assay	11714695	MGI
enables BMP receptor activity	IDA IDA: Inferred from direct assay	11714695	MGI
enables BMP receptor activity	IMP IMP: Inferred from mutant phenotype	10564272	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15239668	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	9268344	MGI
acts upstream of or within BMP signaling pathway	IGI IGI: Inferred from genetic interaction	16049014	MGI
acts upstream of or within BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	16049014	MGI
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	10564272	MGI
acts upstream of or within Mullerian duct regression	IMP IMP: Inferred from mutant phenotype	12368913	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	15136140	MGI
involved in atrioventricular node cell development	IMP IMP: Inferred from mutant phenotype	17998461	MGI
involved in atrioventricular valve development	IMP IMP: Inferred from mutant phenotype	11854453	MGI
involved in cardiac conduction system development	IMP IMP: Inferred from mutant phenotype	16037571	MGI
involved in cardiac right ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	15073157	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	15492776	MGI
acts upstream of or within central nervous system neuron differentiation	IGI IGI: Inferred from genetic interaction	15469980	MGI
involved in chondrocyte differentiation	IDA IDA: Inferred from direct assay	24098149	MGI
acts upstream of or within developmental growth	IMP IMP: Inferred from mutant phenotype	17359964	MGI
involved in dorsal aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	18667463	MGI
acts upstream of or within dorsal/ventral axis specification	IMP IMP: Inferred from mutant phenotype	12923052	MGI
acts upstream of or within dorsal/ventral pattern formation	IGI IGI: Inferred from genetic interaction	15673568	MGI
acts upstream of or within ectoderm development	IMP IMP: Inferred from mutant phenotype	15136139	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	20043884	MGI
acts upstream of or within embryonic morphogenesis	IMP IMP: Inferred from mutant phenotype	15716346	MGI
acts upstream of or within embryonic organ development	IMP IMP: Inferred from mutant phenotype	17359964	MGI
involved in embryonic organ development	IMP IMP: Inferred from mutant phenotype	11854453	MGI
acts upstream of or within endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	16314491	MGI
involved in endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	11854453	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	15136140	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16414041	MGI
involved in fibrous ring of heart morphogenesis	IMP IMP: Inferred from mutant phenotype	16037571	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	16556916	MGI
acts upstream of or within heart formation	IMP IMP: Inferred from mutant phenotype	16943278	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	17359964	MGI
acts upstream of or within hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	16556916	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17359964	MGI
acts upstream of or within lateral mesoderm development	IMP IMP: Inferred from mutant phenotype	16943278	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	16414041	MGI
acts upstream of or within mesendoderm development	IMP IMP: Inferred from mutant phenotype	15136140	MGI
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	17699604	MGI
involved in mitral valve morphogenesis	IMP IMP: Inferred from mutant phenotype	16037571	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	11854453	MGI
involved in negative regulation of muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	10564272	MGI
acts upstream of or within negative regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	17699604	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	17359964	MGI
acts upstream of or within neural crest cell development	IMP IMP: Inferred from mutant phenotype	19793887	MGI
acts upstream of or within neural plate mediolateral regionalization	IMP IMP: Inferred from mutant phenotype	16943278	MGI
acts upstream of or within neural plate pattern specification	IMP IMP: Inferred from mutant phenotype	16943278	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	15716346	MGI
involved in osteoblast differentiation	IDA IDA: Inferred from direct assay	7798324	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	15073157	MGI
involved in outflow tract septum morphogenesis	IMP IMP: Inferred from mutant phenotype	15073157	MGI
acts upstream of or within paraxial mesoderm development	IGI IGI: Inferred from genetic interaction	16943278	MGI
acts upstream of or within paraxial mesoderm development	IMP IMP: Inferred from mutant phenotype	16943278	MGI
acts upstream of or within paraxial mesoderm structural organization	IMP IMP: Inferred from mutant phenotype	16943278	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	15716346	MGI
involved in pharyngeal arch artery morphogenesis	IMP IMP: Inferred from mutant phenotype	15073157	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	17359964	MGI
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	18667463	MGI
involved in positive regulation of cardiac ventricle development	IMP IMP: Inferred from mutant phenotype	18667463	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16414041	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	15716346	MGI
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	21145505	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19416967	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16037571	MGI
acts upstream of or within positive regulation of transforming growth factor beta2 production	IMP IMP: Inferred from mutant phenotype	11854453	MGI
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	18667463	MGI
NOT involved in regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15073157	MGI
involved in regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15073157	MGI
acts upstream of or within regulation of cellular senescence	IGI IGI: Inferred from genetic interaction	22729085	MGI
NOT involved in regulation of endothelial cell differentiation	IDA IDA: Inferred from direct assay	20406889	MGI
NOT involved in regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	20406889	MGI
acts upstream of or within regulation of lateral mesodermal cell fate specification	IGI IGI: Inferred from genetic interaction	16943278	MGI
NOT involved in regulation of neural crest cell differentiation	IMP IMP: Inferred from mutant phenotype	15073157	MGI
NOT involved in regulation of neural crest cell fate specification	IMP IMP: Inferred from mutant phenotype	15073157	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	15716346	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	17699604	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	16943278	MGI
involved in tricuspid valve morphogenesis	IMP IMP: Inferred from mutant phenotype	16037571	MGI
involved in ventricular compact myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	15073157	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	11854453	MGI
involved in ventricular trabecula myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	11854453	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	29415997	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bmpr1a Protein Structure

Activin_recp

TGF_beta_GS

STKc_BMPR1a

0
100
200
300
400
500
532 a.a.

Protein Preferred Names

Protein Names

bone morphogenetic protein receptor type-1A

BMP type-1A receptor	BMP-2/BMP-4 receptor
activin receptor-like kinase 3	serine/threonine-protein kinase receptor R5

Recombinant Bmpr1a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7483	BMPR1A/ALK-3 Protein, Mouse (HEK293, His-Fc)	P36895 (Q24-R152)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01546	BMPR1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01547	Bmpr1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01548	Bmpr1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bmpr1a	NCBI	NCBI:657
Canis familiaris	Bmpr1a	NCBI	NCBI:489077

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