PLD4 - phospholipase D family member 4 Gene

Homo sapiens

Also known as C14orf175

Gene ID: 122618 | Gene type: protein coding

About PLD4

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:104,924,879-104,937,785 (from NCBI)

This gene has 7 transcripts (splice variants), 193 orthologues and 2 paralogues. Biased expression in skin (RPKM 31.7), spleen (RPKM 4.6) and 9 other tissues.

Summary

Predicted to enable single-stranded DNA 5'-3' exodeoxyribonuclease activity. Predicted to be involved in hematopoietic progenitor cell differentiation; phagocytosis; and regulation of cytokine production involved in inflammatory response. Predicted to be located in early endosome and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; phagocytic vesicle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLD4 Products(2)

mRNA	Protein	Name
NM_001308174.2	NP_001295103.1	5'-3' exonuclease PLD4 isoform 1
NM_138790.5	NP_620145.2	5'-3' exonuclease PLD4 isoform 2

PLD4 Protein Structure

PLDc_3

0
100
200
300
400
506 a.a.

Protein Preferred Names

Protein Names

5'-3' exonuclease PLD4

PLD 4

Recombinant PLD4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78019	PLD4 Protein, Human (HEK293, His)	Q96BZ4 (W52-G506)	≥95%

Related Diseases

Diseases

Alias

Paraurethral Gland Cancer

Malignant Tumor Of Paraurethral Gland	Malignant Tumor Of The Paraurethral Gland
Skene Gland Carcinoma	Carcinoma Of The Paraurethral Gland
Paraurethral Gland Carcinoma

Nephrotic Syndrome, Type 7

Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7
NPHS7	Nephrotic Syndrome Type 7
Ig-Mediated Membranoproliferative Glomerulonephritis	Ig-Mediated Mpgn
Immunoglobulin-Mediated Mpgn	Nephrotic Syndrome, Type 7, With Membranoproliferative Glomerulonephritis
Hemolytic Uremic Syndrome, Atypical 7	Nephrotic Syndrome Type 7 With Membranoptoliferative Glomerulonephritis
Hemolytic Uremic Syndrome With Dgke Deficiency	Hus With Dgke Deficiency
Hemolytic Uremic Syndrome Atypical 7	AHUS7
Nephrotic Syndrome 7	Nephrotic Syndrome Type 7 With Membranoproliferative Glomerulonephritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10673	PLD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PLD4	VGNC	VGNC:32998
Mus musculus	PLD4	MGD	MGI:2144765
Macaca mulatta	PLD4	VGNC	VGNC:76100
Rattus norvegicus	PLD4	RGD	RGD:1598308
Felis catus	PLD4	VGNC	VGNC:64214
Canis familiaris	PLD4	VGNC	VGNC:44663
Others	PLD4	NCBI

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